1780-21-8Relevant academic research and scientific papers
Synthesis and crystal structure of n-cyclohexyl-2-nitrobenzamide
Saeed, Aamer,Hussain, Shahid,Bolte, Michael
, p. 924 - 926 (2010)
N-Cyclohexyl-2-nitrobenzamide was synthesized and characterized by spectroscopic data and X-ray diffraction analysis. It crystallizes at room temperature in the monoclinic space group P21/n with cell parameters a = 13.9913(10), b = 8.8475(4), c = 20.5627(15) A, β = 93.278(6)°, V = 2541.3(3) A3 and Z = 8. The structure was refined to final R1 = 0.0626 using all 4950 reflections. The crystal packing is stabilized by N-H...O hydrogen bonds. Graphical Abstract: N-Cyclohexyl-2-nitrobenzamide was synthesized and characterized by spectroscopic data and X-ray diffraction analysis. It crystallizes at room temperature in the monoclinic space group P21/n with cell parameters a = 13.9913(10), b = 8.8475(4), c = 20.5627(15) A, β = 93.278(6)°, V = 2541.3(3) A3 and Z = 8. The structure was refined to final R1 = 0.0626 using all 4950 reflections. The crystal packing is stabilized by N-H...O hydrogen bonds. [Figure not available: see fulltext.]
A B2(OH)4-Mediated Synthesis of 2-Substituted Indazolone and Its Application in a DNA-Encoded Library
Bao, Yapeng,Deng, Zongfa,Feng, Jing,Zhu, Weiwei,Li, Jin,Wan, Jinqiao,Liu, Guansai
supporting information, p. 6277 - 6282 (2020/08/24)
Indazolone cores are among the most common structural components in medicinal chemistry and can be found in many biologically active molecules. In this report, a mild and efficient approach to 2-substituted indazolones via B2(OH)4-mediated reductive N-N b
Nickel-catalyzed reductive amidation of aryl-triazine ethers
Heravi, Majid M.,Panahi, Farhad,Iranpoor, Nasser
supporting information, p. 1992 - 1995 (2020/02/22)
The reaction of activated phenolic compounds, 2,4,6-triaryloxy-1,3,5-triazine (aryl-triazine ethers), with various isocyanates or carbodiimides in the presence of a nickel pre-catalyst resulted in the synthesis of aryl amides in good to excellent yields.
Atom economical synthesis of: N -alkylbenzamides via the iron(III) sulfate catalyzed rearrangement of 2-alkyl-3-aryloxaziridines in water and in the presence of a surfactant
Kra?em, Jamil,Ollevier, Thierry
supporting information, p. 1263 - 1267 (2017/08/15)
A green and mild synthetic route to N-alkylbenzamides involves eco-friendly one pot synthesis of 2-alkyl-3-aryloxaziridines from N-alkylamines and benzaldehydes followed by iron(iii) sulfate catalyzed rearrangement to the corresponding amides in water as the solvent and in the presence of sodium dodecyl sulfate as the surfactant. This green approach affords N-alkylbenzamides in high overall yields under simple and minimum manipulation.
A Study on the Activation of Carboxylic Acids by Means of 2-Chloro-4,6-dimethoxy-1,3,5-triazine and 2-Chloro-4,6-diphenoxy-1,3,5-triazine
Kaminski,Paneth,Rudzinski
, p. 4248 - 4255 (2007/10/03)
Activation of carboxylic function by means of 2-chloro-4,6-disubstituted-1,3,5-triazines 1 and 2 leading to triazine esters was found to be a multistep process with participation of quarternary triazinylammonium salts 3-6 as the intermediates, with the rate of reaction strongly dependent on the structure of the tertiary amine. The studies on alkylation of tertiary amines with CDMT revealed the two-step process AN + DN, and zwitterionic addition product 9 was identified by 1H NMR spectroscopy. Semiempirical modeling of the reaction as well as measured nitrogen and chlorine isotope effects also support this mechanism.
