1780-38-7

Basic information

• Product Name: Pyrimidine, 2,4,6-trichloro-5-ethyl-
• Synonyms: Pyrimidine, 2,4,6-trichloro-5-ethyl-
• CAS NO: 1780-38-7
• Molecular Formula: C₆H₅Cl₃N₂
• Molecular Weight: 211.48
• Product Categories: API intermediates
• Mol File: 1780-38-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 75-77 °C(Solv: ethyl ether (60-29-7); methanol (67-56-1))
• Boiling Point: 244.2 °C at 760 mmHg
• Flash Point: 125.1 °C
• Appearance: /
• Density: 1.463 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -6.80±0.39(Predicted)
• CAS DataBase Reference: Pyrimidine, 2,4,6-trichloro-5-ethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrimidine, 2,4,6-trichloro-5-ethyl-(1780-38-7)
• EPA Substance Registry System: Pyrimidine, 2,4,6-trichloro-5-ethyl-(1780-38-7)

Safety Data

• Hazardous Substances Data: 1780-38-7(Hazardous Substances Data)

Usage

General Description

"Pyrimidine, 2,4,6-trichloro-5-ethyl-" is a chemical compound with a specific molecular structure belonging to the group of pyrimidines, which are aromatic heterocyclic organic compounds similar to pyridine. The name refers to its unique structure, which consists of a pyrimidine ring with three chlorine atoms at positions 2, 4 and 6, and an ethyl group at position 5. The properties, synthesis, reactions, and potential uses of this particular compound can vary and would need to be explored in more detail. Like other pyrimidine derivatives, it might have potential biological activity or could be used as building blocks in the synthesis of more complex chemical compounds. However, its specific properties and potential applications would largely depend on its precise chemical structure and the conditions under which it is used.

Upstream product

• 133-13-1 ethyl diethyl malonate 
• 2518-72-1 5-ethyl barbituric acid 

Downstream Products

• 24867-19-4 5-ethyl-pyrimidine-2,4,6-triamine 
• 6343-69-7 6-chloro-5-ethylpyrimidine-2,4-diamine 
• 81316-68-9 5-ethyl-2,6-dichloro-pyrimidin-4-ylamine 
• 20295-24-3 5-ethyl-6-chloro-2,4-pyrimidinedione 
• 1006300-13-5 2,4-Bis-benzyloxy-6-chloro-5-ethyl-pyrimidine 
• 96494-17-6 5-ethyl-2,4,6-trimethoxy-pyrimidine 
• 1612757-33-1 6-[(3,5-dimethylphenyl)fluoromethyl]-5-ethyl-1-[[(2-methylallyl)oxy]methyl]pyrimidine-2,4(1H,3H)-dione 
• 1612757-32-0 1-[(allyloxy)methyl]-6-[(3,5-dimethylphenyl)-fluoromethyl]-5-ethylpyrimidine-2,4(1H,3H)-dione 
• 1612757-27-3 6-[(3,5-dimethylphenyl)fluoromethyl]-1-(ethoxymethyl)-5-ethylpyrimidine-2,4(1H,3H)-dione 
• 1612757-26-2 6-[(3,5-dimethylphenyl)fluoromethyl]-5-ethylpyrimidine-2,4(1H,3H)-dione 
• 1612757-25-1 6-[(3,5-dimethylphenyl)hydroxymethyl]-5-ethylpyrimidine-2,4(1H,3H)-dione 
• 1612757-30-8 3-{4-[((6-((3,5-dimethylphenyl)fluoromethyl)-5-ethyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)methyl]phenyl}propiolaldehyde 
• 1612757-29-5 6-[(3,5-dimethylphenyl)fluoromethyl]-5-ethyl-1-{[[4-(3-hydroxyprop-1-ynyl)benzyl]oxy]methyl}pyrimidine-2,4(1H,3H)-dione 
• 1612757-28-4 6-[(3,5-dimethylphenyl)fluoromethyl]-5-ethyl-1-[[(4-iodobenzyl)oxy]methyl]pyrimidine-2,4(1H,3H)-dione 

Relevant articles and documents

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Synthesis and antimicrobial activity of some novel 5-alkyl-6-substituted uracils and related derivatives

6-Chloro-5-ethyl-, n-propyl- and isopropyluracils 5a-c were efficiently prepared from the corresponding 5-alkybarbituric acids 3a-c via treatment with phosphorus oxychloride and N,N-dimethylaniline to yield the corresponding 5-alkyl-2,4,6-trichloropyrimidines 4a-c, which were selectively hydrolyzed by heating in 10% aqueous sodium hydroxide for 30 minutes. The reaction of compounds 5a-c with 1-substituted piperazines yielded the corresponding 5-alkyl-6-(4-substituted-1-piperazinyl)uracils 6a-j. The target 8-alkyltetrazolo[1,5-f]pyrimidine-5,7(3H,6H)-diones 7a-c were prepared via the reaction of 5a-c with sodium azide. Compounds 6a-j and 7a-c were tested for in vitro activities against a panel of Gram-positive and Gram-negative bacteria and the yeast-like pathogenic fungus Candida albicans. Compound 6h displayed potent broad-spectrum antibacterial activity, while compound 6b showed moderate activity against the Gram-positive bacteria. All the tested compounds were practically inactive against Candida albicans.

Non-nucleoside HIV-1 reverse transcriptase inhibitors, part 7. Synthesis, antiviral activity, and 3D-QSAR investigations of novel 6-(1-naphthoyl) HEPT analogues

A series of novel 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) analogues bearing a 6-(1-naphthoyl) group of non-nucleoside human immunodeficiency virus (HIV) reverse transcriptase inhibitors were synthesized and evaluated for their activity against HIV-1 and HIV-2. It was found that most of these compounds showed good activity against HIV-1. Among them, compound 5-isopropyl-6-(1-naphthoyl)-1-[(2E)-3-phenylallyl]-2,4-pyrimidinedione (23) displayed the greatest inhibitory potency (IC50=0.14 μM), which is about 35-fold more active than HEPT and DDI. To rationalize the relationships between structure and activity of these novel compounds, a three-dimensional quantitative structure-activity relationship (3D-QSAR) model was also generated. The results provided a tool for guiding the further design of more potent antiviral agents and for predicting the affinity of related compounds.