1612757-25-1

Basic information

• Product Name: 6-[(3,5-dimethylphenyl)hydroxymethyl]-5-ethylpyrimidine-2,4(1H,3H)-dione
• Synonyms: 6-[(3,5-dimethylphenyl)hydroxymethyl]-5-ethylpyrimidine-2,4(1H,3H)-dione
• CAS NO: 1612757-25-1
• Molecular Weight: 274.32
• Mol File: 1612757-25-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-[(3,5-dimethylphenyl)hydroxymethyl]-5-ethylpyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 6-[(3,5-dimethylphenyl)hydroxymethyl]-5-ethylpyrimidine-2,4(1H,3H)-dione(1612757-25-1)
• EPA Substance Registry System: 6-[(3,5-dimethylphenyl)hydroxymethyl]-5-ethylpyrimidine-2,4(1H,3H)-dione(1612757-25-1)

Safety Data

• Hazardous Substances Data: 1612757-25-1(Hazardous Substances Data)

Upstream product

• 1204750-02-6 2-(2,6-dichloro-5-ethylpyrimidin-4-yl)-2-(3,5-dimethylphenyl)acetonitrile 
• 64-17-5 ethanol 
• 1612757-24-0 4-[(3,5-dimethylphenyl)fluoromethyl]-5-ethyl-2,6-dimethoxypyrimidine 
• 39101-54-7 3,5-dimethylphenylacetonitrile 
• 1780-38-7 2,4,6-trichloro-5-ethylpyrimidine 
• 1612757-23-9 (3,5-dimethylphenyl)(5-ethyl-2,6-dimethoxypyrimidin-4-yl)methanol 
• 171048-68-3 (3,5-dimethylphenyl)(5-ethyl-2,6-dimethoxypyrimidin-4-yl)methanone 
• 171048-67-2 (6-(3,5-dimethylbenzoyl)-5-ethylpyrimidine)-2,4(1H,3H)-dione 

Downstream Products

• 1612757-28-4 6-[(3,5-dimethylphenyl)fluoromethyl]-5-ethyl-1-[[(4-iodobenzyl)oxy]methyl]pyrimidine-2,4(1H,3H)-dione 
• 1612757-34-2 6-[(3,5-dimethylphenyl)fluoromethyl]-5-ethyl-3-[[(4-iodobenzyl)oxy]methyl]pyrimidine-2,4(1H,3H)-dione 
• 1612757-29-5 6-[(3,5-dimethylphenyl)fluoromethyl]-5-ethyl-1-{[[4-(3-hydroxyprop-1-ynyl)benzyl]oxy]methyl}pyrimidine-2,4(1H,3H)-dione 
• 1612757-30-8 3-{4-[((6-((3,5-dimethylphenyl)fluoromethyl)-5-ethyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)methyl]phenyl}propiolaldehyde 
• 1612757-26-2 6-[(3,5-dimethylphenyl)fluoromethyl]-5-ethylpyrimidine-2,4(1H,3H)-dione 
• 1612757-27-3 6-[(3,5-dimethylphenyl)fluoromethyl]-1-(ethoxymethyl)-5-ethylpyrimidine-2,4(1H,3H)-dione 
• 1612757-33-1 6-[(3,5-dimethylphenyl)fluoromethyl]-5-ethyl-1-[[(2-methylallyl)oxy]methyl]pyrimidine-2,4(1H,3H)-dione 

Relevant articles and documents

Synthesis of novel fluoro analogues of MKC442 as microbicides

Novel analogues of MKC442 (6-benzyl-1-(ethoxymethyl)-5-isopropylpyrimidine- 2,4(1H,3H)-dione) were synthesized by reaction of 6-[(3,5-dimethylphenyl) fluoromethyl]-5-ethyluracil (5) with ethoxymethyl chloride and formaldehyde acetals. The Sonogashira reaction was carried out on the N1-(p-iodobenzyl)oxy] methyl derivative of compound 5 using propagyl alcohol to afford compound 12 (YML220). The latter compound was selected for further studies since it showed the most potent and selective activity in vitro against wild-type HIV-1 and non-nucleoside reverse transcriptase inhibitor-, nucleoside reverse transcriptase inhibitor-, and protease inhibitor-resistant mutants and a wide range of HIV-1 clinical isolates. 12 also showed microbicidal activity in long-term assays with heavily infected MT-4 cells.