178034-25-8Relevant academic research and scientific papers
Synthesis of potent β-D-glucocerebrosidase inhibitors: N-alkyl-β-valienamines
Ogawa, Seiichiro,Ashiuraa, Makoto,Uchida, Chikara,Watanabe, Shinsuke,Yamazaki, Chihiro,Yamagishib, Kiwamu,Inokuchi, Jin-Ichi
, p. 929 - 932 (1996)
Six homologous derivatives (N-butyl 3a, hexyl 3b, octyl 3c, decyl 3d, tetradecyl 3e and stearyl 3f) of β-valienamine were synthesized. All have been shown to be potent and specific inhibitors of β-glucocerebrosidase, and to have no potency against glucosylceramide synthase (mouse liver microsomes). Among them, the N-octyl derivative possesses the strongest activity (IC50 3 x 10-8 M), being almost 10-fold more potent compared to the unsaturated 5a-carba-glucosylceramide 1. Compounds 3b and 3c are also moderate inhibitors of α-glucosidase (Baker's yeast).
ACID ADDITION SALT OF CARBASUGAR AMINE DERIVATIVE
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Page/Page column 19-20, (2008/06/13)
An acid addition salt of a carba-sugar amine derivative represented by the following formula (1): wherein R1 and R2 each independently represents a hydrogen atom, or an alkyl group, an alkenyl group, an alkynyl group, an acyl group,
