Bioorganic and Medicinal Chemistry Letters p. 929 - 932 (1996)
Update date:2022-08-04
Topics:
Ogawa, Seiichiro
Ashiuraa, Makoto
Uchida, Chikara
Watanabe, Shinsuke
Yamazaki, Chihiro
Yamagishib, Kiwamu
Inokuchi, Jin-Ichi
Six homologous derivatives (N-butyl 3a, hexyl 3b, octyl 3c, decyl 3d, tetradecyl 3e and stearyl 3f) of β-valienamine were synthesized. All have been shown to be potent and specific inhibitors of β-glucocerebrosidase, and to have no potency against glucosylceramide synthase (mouse liver microsomes). Among them, the N-octyl derivative possesses the strongest activity (IC50 3 x 10-8 M), being almost 10-fold more potent compared to the unsaturated 5a-carba-glucosylceramide 1. Compounds 3b and 3c are also moderate inhibitors of α-glucosidase (Baker's yeast).
View MoreNanyang Tianhua pharmaceutical Co.,Ltd.
Contact:+8618639816203
Address:Longsheng Industrial Park
Shanghai Hohance Chemical Co., ltd
Contact:13914753421
Address:Fl.5;Bld. 70, Lane 1500; Xinfei Road
Zhejiang Sanmei Chemical Industry Co., Ltd
Contact:86-579-87633213
Address:Huchu Industrial Zone, Qingnian Rd., Wuyi County, Zhejiang Prov., China.
website:http://www.synchemie.com/
Contact:+86-574-87642758
Address:Room 901, Yinyi Bund Building, 132 Renmin Road
Guangzhou PI & PI Biotech Inc. Ltd.
Contact:+86-20-81716320
Address:Suite 501,198 Kaiyuan Ave.,Science City, Guangzhou,China
Doi:10.1021/ic990178q
(1999)Doi:10.1016/0022-328X(95)06036-V
(1996)Doi:10.1016/S0040-4039(03)01831-8
(2003)Doi:10.1016/S0960-894X(98)00475-2
(1998)Doi:10.1021/jo960773z
(1996)Doi:10.1039/jr9610001228
(1961)