178064-02-3

Basic information

• Product Name: NOCICEPTIN (1-13) AMIDE
• Synonyms: NOCICEPTIN (1-13) AMIDE;NOCICEPTIN (1-13)NH2;PHE-GLY-GLY-PHE-THR-GLY-ALA-ARG-LYS-NH2;PHE-GLY-GLY-PHE-THR-GLY-ALA-ARG-LYS-SER-ALA-ARG-LYS-NH2;ORPHANIN FQ (1-13) AMIDE;H-PHE-GLY-GLY-PHE-THR-GLY-ALA-ARG-LYS-SER-ALA-ARG-LYS-NH2;Nociceptin (1-13)-NH2/ Orphanin FQ;Nociceptin (1-13) aMide Orphanin FQ (1-13) aMide
• CAS NO: 178064-02-3
• Molecular Formula: C61H100N22O15
• Molecular Weight: 1381.59
• Product Categories: Opioid receptor and opioid-like receptor
• Mol File: 178064-02-3.mol

Chemical Properties

• Appearance: /
• Storage Temp.: -15°C
• CAS DataBase Reference: NOCICEPTIN (1-13) AMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: NOCICEPTIN (1-13) AMIDE(178064-02-3)
• EPA Substance Registry System: NOCICEPTIN (1-13) AMIDE(178064-02-3)

Safety Data

• Hazardous Substances Data: 178064-02-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
NOCICEPTIN (1-13) AMIDE is used as a potential therapeutic agent for pain management due to its ability to modulate pain perception. It is being explored for the development of new medications aimed at alleviating chronic and acute pain conditions.
Used in Neurological Research:
NOCICEPTIN (1-13) AMIDE is used as a research tool for understanding the mechanisms of pain and emotional regulation in the brain and spinal cord. Its role in these processes aids scientists in identifying novel targets for the treatment of neurological disorders.
Used in Mood Disorder Treatment Development:
NOCICEPTIN (1-13) AMIDE is used as a potential therapeutic target for the development of treatments for mood disorders, given its demonstrated anxiolytic and antidepressant-like effects in animal studies. This makes it a candidate for further research into its efficacy in managing conditions such as anxiety and depression.

Upstream product

• 29022-11-5 N-(fluoren-9-ylmethoxycarbonyl)glycine 
• 35661-39-3 N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine 
• 35661-40-6 N-Fmoc L-Phe 
• 71989-33-8 Fmoc-Ser(tBu)-OH 
• 71989-26-9 Fmoc-Lys(tert-butoxycarbonyl) 
• 71989-35-0 Fmoc-Thr(tBu)-OH 

Relevant articles and documents

Novel Mixed NOP/Opioid Receptor Peptide Agonists

The nociceptin/orphanin FQ (N/OFQ)/N/OFQ receptor (NOP) system controls different biological functions including pain and cough reflex. Mixed NOP/opioid receptor agonists elicit similar effects to strong opioids but with reduced side effects. In this work, 31 peptides with the general sequence [Tyr/Dmt1,Xaa5]N/OFQ(1-13)-NH2 were synthesized and pharmacologically characterized for their action at human recombinant NOP/opioid receptors. The best results in terms of NOP versus mu opioid receptor potency were obtained by substituting both Tyr1 and Thr5 at the N-terminal portion of N/OFQ(1-13)-NH2 with the noncanonical amino acid Dmt. [Dmt1,5]N/OFQ(1-13)-NH2 has been identified as the most potent dual NOP/mu receptor peptide agonist so far described. Experimental data have been complemented by in silico studies to shed light on the molecular mechanisms by which the peptide binds the active form of the mu receptor. Finally, the compound exerted antitussive effects in an in vivo model of cough.