178064-02-3

Basic information

• Product Name: NOCICEPTIN (1-13) AMIDE
• Synonyms: NOCICEPTIN (1-13) AMIDE;NOCICEPTIN (1-13)NH2;PHE-GLY-GLY-PHE-THR-GLY-ALA-ARG-LYS-NH2;PHE-GLY-GLY-PHE-THR-GLY-ALA-ARG-LYS-SER-ALA-ARG-LYS-NH2;ORPHANIN FQ (1-13) AMIDE;H-PHE-GLY-GLY-PHE-THR-GLY-ALA-ARG-LYS-SER-ALA-ARG-LYS-NH2;Nociceptin (1-13)-NH2/ Orphanin FQ;Nociceptin (1-13) aMide Orphanin FQ (1-13) aMide
• CAS NO: 178064-02-3
• Molecular Formula: C61H100N22O15
• Molecular Weight: 1381.59
• Product Categories: Opioid receptor and opioid-like receptor
• Mol File: 178064-02-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: -15°C
• CAS DataBase Reference: NOCICEPTIN (1-13) AMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: NOCICEPTIN (1-13) AMIDE(178064-02-3)
• EPA Substance Registry System: NOCICEPTIN (1-13) AMIDE(178064-02-3)

Safety Data

• Hazardous Substances Data: 178064-02-3(Hazardous Substances Data)

Usage

General Description

Nociceptin (1-13) amide, also known as Nociceptin (1-13) peptide, is a chemical compound that is a fragment derived from the nociceptin peptide. Nociceptin is a neuropeptide in the brain and spinal cord that plays a role in pain modulation and is also involved in various physiological and pathological processes. Nociceptin (1-13) amide has been studied for its potential therapeutic applications, particularly for its ability to modulate pain perception and potentially be used in the development of new pain management medications. Additionally, it has been shown to have anxiolytic and antidepressant-like effects in animal studies, making it a potential target for the development of treatments for mood disorders. Overall, Nociceptin (1-13) amide is a promising compound with potential applications in the field of pain management and emotional regulation.

Upstream product

• 29022-11-5 N-(fluoren-9-ylmethoxycarbonyl)glycine 
• 35661-39-3 N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine 
• 35661-40-6 N-Fmoc L-Phe 
• 71989-33-8 Fmoc-Ser(tBu)-OH 
• 71989-26-9 Fmoc-Lys(tert-butoxycarbonyl) 
• 71989-35-0 Fmoc-Thr(tBu)-OH 

Relevant articles and documents

Novel Mixed NOP/Opioid Receptor Peptide Agonists

The nociceptin/orphanin FQ (N/OFQ)/N/OFQ receptor (NOP) system controls different biological functions including pain and cough reflex. Mixed NOP/opioid receptor agonists elicit similar effects to strong opioids but with reduced side effects. In this work, 31 peptides with the general sequence [Tyr/Dmt1,Xaa5]N/OFQ(1-13)-NH2 were synthesized and pharmacologically characterized for their action at human recombinant NOP/opioid receptors. The best results in terms of NOP versus mu opioid receptor potency were obtained by substituting both Tyr1 and Thr5 at the N-terminal portion of N/OFQ(1-13)-NH2 with the noncanonical amino acid Dmt. [Dmt1,5]N/OFQ(1-13)-NH2 has been identified as the most potent dual NOP/mu receptor peptide agonist so far described. Experimental data have been complemented by in silico studies to shed light on the molecular mechanisms by which the peptide binds the active form of the mu receptor. Finally, the compound exerted antitussive effects in an in vivo model of cough.