17811-36-8

Upstream product

• 17811-34-6 6-Acetoxy-4-methoxy-5-methyl-1(3H)-isobenzofuranon 
• 219298-64-3 2-methoxy-3-methyl-4-(tetrahydro-2H-pyran-2-yloxy)benzaldehyde 
• 124-38-9 carbon dioxide 
• 219646-70-5 3-methoxy-4-methyl-5-(3-methyl-2-butenyloxy)phthalic acid 
• 219646-66-9 dimethyl 3-methoxy-4-methyl-5-(3-methyl-2-butenyloxy)phthalate 
• 219646-73-8 5-acetoxy-3-methoxy-4-methylphthalic anhydride 
• 219646-64-7 dimethyl 5-hydroxy-3-methoxy-4-methylphthalate 
• 52231-37-5 4,6-Dihydroxy-5-methyl-1(3H)-isobenzofuranon 
• 74-88-4 methyl iodide 

Downstream Products

• 52231-37-5 4,6-Dihydroxy-5-methyl-1(3H)-isobenzofuranon 
• 17811-32-4 4-methoxy-5-methyl-6-((3-methylbut-2-en-1-yl)oxy)isobenzofuran-1(3H)-one 

Relevant academic research and scientific papers

Incorporation of carbon dioxide into phthalides: Via ligand-free copper-catalyzed direct carboxylation of benzoxasiloles

The direct carboxylation of benzoxasiloles with carbon dioxide proceeded smoothly under mild conditions using copper iodide as a catalyst to afford phthalides after an acid work-up. Broad substrate scope and application of this methodology for the synthesis of natural products highlight the synthetic utility of this protocol.

Synthesis based on cyclohexadienes: Part 261 - Total synthesis of some naturally occurring phthalides from Alternaria species

Total synthesis of the naturally occurring phytotoxic phthalides, silvaticol 7, zinniol 5 and the phthalides 1 and 2, is reported from the substrate 16 derived from the Alder-Rickert reaction of 1-methoxy-2-methyl-3-trimethylsilyloxycyclohexa-1,3-diene 15