17819-25-9Relevant academic research and scientific papers
Synthesis of 3-furanyl-4,5-dihydroisoxazole derivatives via cycloaddition and their antibacterial evaluation
De Andrade Danin Barbosa, Gabriela,De Aguiar, Alcino Palermo,De Carvalho, Erika Martins,Da Rocha Nogueira, Joseli Maria
, p. 364 - 369 (2019/06/20)
Background: Antimicrobial resistance is a major threat to human health. So this manuscript describes the synthesis of five different 3,5-disubstituted 4,5-dihydroisoxazoles with antimicrobial activity. Methods: They were obtained from nitrile oxide cycloaddition derived from 2-furaldehyde and 5-nitro-2-furaldehyde to different dipolarophiles (acrylamide, ethyl acrylate and styrene). All heterocycles were isolated (30-50 %) and characterized by FTIR, MS,1H and13C NMR, as they were also evaluated against Gram-positive and Gram-negative bacteria. Results and Conclusion: All products showed bioactivity against all bacteria, however, the heterocycle 3-(5-nitro-2-furanyl)-5-carboxylamide-4,5-dihydroisoxazole (6b) presented the lowest value for the minimum inhibition concentration (MIC - 14 μg/mL).
