178201-91-7Relevant academic research and scientific papers
An efficient enantioselective synthesis of the D1 agonist (5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopenta[c] phenanthrene-9,10-diol (A-86929)
Ehrlich, Paul P.,Ralston, Jeffrey W.,Michaelides, Michael R.
, p. 2782 - 2785 (1997)
(5aR,11bS)-4,5,5a,6,7,11b-Hexahydro-2-propyl-3-thia-5-azacyclopenta[c] phenanthrene-9,10-diol (A86929, 1), a potent selective dopamine D1 agonist, was synthesized enantioselectively from D-aspartic acid. Key features of the 10-step synthesis are the follo
PROCESS FOR PREPARING CHIRAL TETRACYCLIC DOPAMINERGIC COMPOUNDS
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, (2008/06/13)
A process for preparing a chiral tetracyclic compound of formula: STR1 wherein R is hydrogen or a C 1-C 6-alkyl group and Z is oxygen, sulfur or--CH=CH--, the compounds having uses as dopamine agonists. The process involves reacting a chiral starting mate
