178201-92-8Relevant articles and documents
An efficient enantioselective synthesis of the D1 agonist (5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopenta[c] phenanthrene-9,10-diol (A-86929)
Ehrlich, Paul P.,Ralston, Jeffrey W.,Michaelides, Michael R.
, p. 2782 - 2785 (2007/10/03)
(5aR,11bS)-4,5,5a,6,7,11b-Hexahydro-2-propyl-3-thia-5-azacyclopenta[c] phenanthrene-9,10-diol (A86929, 1), a potent selective dopamine D1 agonist, was synthesized enantioselectively from D-aspartic acid. Key features of the 10-step synthesis are the follo