178209-29-5

Basic information

• Product Name: 5H-Cyclopenta[b]pyridin-3-amine,6,7-dihydro-(9CI)
• Synonyms: 5H-Cyclopenta[b]pyridin-3-amine,6,7-dihydro-(9CI);5H,6H,7H-cyclopenta[b]pyridin-3-aMine;5H-Cyclopenta[b]pyridin-3-aMine, 6,7-dihydro-;6,7-Dihydro-5H-[1]pyrindin-3-ylaMine
• CAS NO: 178209-29-5
• Molecular Formula: C8H10N2
• Molecular Weight: 134.181
• Product Categories: PYRIDINE;Amines;Fused Ring Systems
• Mol File: 178209-29-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 308.735ºC at 760 mmHg
• Flash Point: 166.087ºC
• Appearance: /
• Density: 1.177g/cm3
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.634
• CAS DataBase Reference: 5H-Cyclopenta[b]pyridin-3-amine,6,7-dihydro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 5H-Cyclopenta[b]pyridin-3-amine,6,7-dihydro-(9CI)(178209-29-5)
• EPA Substance Registry System: 5H-Cyclopenta[b]pyridin-3-amine,6,7-dihydro-(9CI)(178209-29-5)

Safety Data

• Hazardous Substances Data: 178209-29-5(Hazardous Substances Data)

Usage

General Description

5H-Cyclopenta[b]pyridin-3-amine,6,7-dihydro-(9CI) is a chemical compound with the molecular formula C10H13N. It is a cyclic amine consisting of a cyclopentane ring fused to a pyridine ring with an amine group at the third position. 5H-Cyclopenta[b]pyridin-3-amine,6,7-dihydro-(9CI) is also known as 6,7-dihydro-5H-cyclopenta[b]pyridin-3-amine and is mainly used in pharmaceutical research as a building block for the synthesis of various biologically active molecules. It is also a potential drug target for the treatment of neurological and psychiatric disorders due to its interaction with certain receptors and enzymes in the brain. Additionally, this compound has potential applications in the field of organic synthesis and medicinal chemistry.

InChI:InChI=1/C8H10N2/c9-7-4-6-2-1-3-8(6)10-5-7/h4-5H,1-3,9H2

Upstream product

• 84531-36-2 6,7-dihydro-3-nitro-5H-cyclopentapyridine 

Downstream Products

• 1421429-82-4 phenyl 6,7-dihydro-5H-cyclopenta[b]pyridin-3-ylcarbamate 

Relevant articles and documents

Substituted Bicyclic Aromatic Carboxamide and Urea Compounds as Vanilloid Receptor Ligands

Substituted bicyclic aromatic carboxamide and urea compounds as vanilloid receptor ligands, pharmaceutical compositions containing these compounds, and a method of using these compounds in the treatment and/or inhibition of pain and further diseases and/or disorders mediated at least in part via the vanilloid receptor 1 (VR1/TRPV1).

Synthesis and structure-activity relationships of fused imidazopyridines: A new series of benzodiazepine receptor ligands

2-Arylimidazo[4,5-c]quinolines and analogous fused imidazopyridines were synthesized and evaluated as benzodiazepine receptor ligands. Affinity to the receptors was greatly affected by the bulkiness of the aryl group at the 2- position, compared to the pyrazoloquinolines such as CGS-9896. Derivatives with an isoxazole moiety at the 2-position showed high binding affinity and in vivo activity. In the imidazo[4,5-c]quinoline series, substitution at the 6-position decreased or abolished activity. Most derivatives with an unsubstituted isoxazolyl group showed antagonist or inverse agonist activity except for the 7-halo analogues, which exhibited agonist activity. On the other hand, 5-methylisoxazol-3-yl or 3-methylisoxazol-5-yl derivatives generally exhibited agonist activity. A similar substitution effect on the isoxazole moiety was observed in the imidazopyridines fused with a nonaromatic ring. From the detailed pharmacological evaluation, S-8510, 2- (3-isoxazolyl)-3,6,7,9-tetrahydroimidazo[4,5-d]pyrano[4,3-b]pyridine monophosphate, possessing weak inverse agonist activity was selected as a therapeutic candidate for the treatment of some symptoms of senile dementia.