178210-61-2

Upstream product

• 134-20-3 2-carbomethoxyaniline 
• 178210-59-8 2-(Chlorooxalyl-amino)-benzoic acid methyl ester 
• 178210-58-7 2-(2-aminobenzoylmethyl)-1,3-dioxolane 
• 153813-82-2 2-(2-nitrobenzoylmethyl)-1,3-dioxolane 
• 178210-60-1 2-{[2-(2-[1,3]Dioxolan-2-yl-acetyl)-phenylaminooxalyl]-amino}-benzoic acid methyl ester 

Downstream Products

• 132911-53-6 Secofascaplysin A 

Relevant academic research and scientific papers

Low-valent titanium induced indole formation: Syntheses of secofascaplysin, indolopyridocoline and an endothelin-receptor-antagonist

The versatility of a titanium-induced reductive oxo-amide coupling reaction is illustrated by the syntheses of the alkaloids secofrascaplysin 8 and indolopyridocoline 14 as well as by an efficient and flexible approach to the arylated indole-2-carboxylic acid 4, which has recently been disclosed as a promising endothelin-receptor-antagonist. Depending on the particular substitution pattern in the substrates, either pre-formed titanium on graphite or low-valent titanium formed in situ ('instant conditions') are the preferred coupling agents for reductive heterocycle syntheses of this type.