178243-92-0

Basic information

• Product Name: Cyclohexane, 2-ethynyl-4-methyl-1-(1-methylethyl)-, (1S,2R,4R)- (9CI)
• Synonyms: Cyclohexane, 2-ethynyl-4-methyl-1-(1-methylethyl)-, (1S,2R,4R)- (9CI)
• CAS NO: 178243-92-0
• Molecular Formula: C12H20
• Molecular Weight: 164.2872
• Product Categories: ISOPROPYL
• Mol File: 178243-92-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Cyclohexane, 2-ethynyl-4-methyl-1-(1-methylethyl)-, (1S,2R,4R)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexane, 2-ethynyl-4-methyl-1-(1-methylethyl)-, (1S,2R,4R)- (9CI)(178243-92-0)
• EPA Substance Registry System: Cyclohexane, 2-ethynyl-4-methyl-1-(1-methylethyl)-, (1S,2R,4R)- (9CI)(178243-92-0)

Safety Data

• Hazardous Substances Data: 178243-92-0(Hazardous Substances Data)

Relevant articles and documents

Enantiospecific Alkynylation of Alkylboronic Esters

Enantioenriched secondary and tertiary alkyl pinacolboronic esters undergo enantiospecific deborylative alkynylation through a Zweifel-type alkenylation followed by a 1,2-elimination reaction. The process involves use of α-lithio vinyl bromide or vinyl carbamate species, for which application to Zweifel-type reactions has not previously been explored. The resulting functionalized 1,1-disubstituted alkenes undergo facile base-mediated elimination to generate terminal alkyne products in high yield and excellent levels of enantiospecificity over a wide range of pinacolboronic ester substrates. Furthermore, along with terminal alkynes, internal and silyl-protected alkynes can be formed by simply introducing a suitable carbon- or silicon-based electrophile after the base-mediated 1,2-elimination reaction. Enantiospecific alkynylation: Enantioenriched secondary and tertiary alkyl pinacolboronic esters undergo enantiospecific deborylative alkynylation through a Zweifel-type alkenylation followed by a 1,2-elimination reaction to give alkynes in high yield and essentially complete enantiospecificity.