178247-84-2

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 178247-82-0 methyl (4S,5R)-3-tert-butoxycarbonyl-2,2-dimethyl-4-cyclopropyl-5-oxazolidinecarboxylate 
• 178247-81-9 methyl (2R,3S)-3-cyclopropyl-3-tert-butoxycarbonylamino-2-hydroxypropionate 
• 178248-35-6 methyl (2R,3S)-3-cyclopropyl-3-azido-2-hydroxypropionate 
• 178248-33-4 methyl (2S,3R)-3-cyclopropyl-2,3-dihydroxypropionate 
• 178248-34-5 methyl (2R,3R)-3-cyclopropyl-2,3-epoxypropionate 
• 98272-33-4 methyl 3-cyclopropylacrylate 
• 95603-44-4 7,10-di-(2,2,2-trichloroethyloxycarbonyl)-10-deacetylbaccatin III 
• 178247-83-1 (4S,5R)-3-tert-butoxycarbonyl-2,2-dimethyl-4-cyclopropyl-5-oxazolidinecarboxylic acid 

Downstream Products

• 178247-87-5 C₄₆H₅₅Cl₆NO₁₈ 
• 244121-78-6 C₅₄H₆₇N₃O₂₀ 
• 178247-97-7 C₅₄H₆₇N₃O₂₀ 
• 244121-79-7 C₅₅H₆₉N₃O₂₀ 
• 244121-81-1 C₅₇H₇₂N₂O₂₁ 
• 178247-96-6 C₆₀H₆₉Cl₆N₃O₂₄ 
• 178247-85-3 C₄₁H₄₇Cl₆NO₁₆ 

Relevant academic research and scientific papers

Synthesis of taxoids 5. Synthesis and evaluation of novel water-soluble prodrugs of a 3'-desphenyl-3'-cyclopropyl analogue of docetaxel

A novel 3'-desphenyl-3'-cyclopropyl analogue of docetaxel was synthesized from 10-deacetyl-baccatin III. The cytotoxicity of the new taxoid was evaluated against several human tumor cell lines, and it had ca. 20 times stronger activity against human colon cancer cell lines (WiDr and Colon 320) than that of docetaxel. This taxoid was converted to its water-soluble prodrugs that have 2'-substituted amino acid derivatives with spacer. The prodrugs had good solubility in saline and showed more potent antitumor activity against B 16 melanoma in mice than that of docetaxel.