244121-78-6

Basic information

• Product Name: C₅₄H₆₇N₃O₂₀
• CAS NO: 244121-78-6
• Molecular Weight: 1078.13
• Mol File: 244121-78-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₅₄H₆₇N₃O₂₀(CAS DataBase Reference)
• NIST Chemistry Reference: C₅₄H₆₇N₃O₂₀(244121-78-6)
• EPA Substance Registry System: C₅₄H₆₇N₃O₂₀(244121-78-6)

Safety Data

• Hazardous Substances Data: 244121-78-6(Hazardous Substances Data)

Upstream product

• 178247-84-2 C₄₉H₅₉Cl₆NO₁₈ 
• 178247-87-5 C₄₆H₅₅Cl₆NO₁₈ 
• 178247-83-1 (4S,5R)-3-tert-butoxycarbonyl-2,2-dimethyl-4-cyclopropyl-5-oxazolidinecarboxylic acid 
• 178247-82-0 methyl (4S,5R)-3-tert-butoxycarbonyl-2,2-dimethyl-4-cyclopropyl-5-oxazolidinecarboxylate 
• 178247-81-9 methyl (2R,3S)-3-cyclopropyl-3-tert-butoxycarbonylamino-2-hydroxypropionate 
• 178248-35-6 methyl (2R,3S)-3-cyclopropyl-3-azido-2-hydroxypropionate 
• 178248-33-4 methyl (2S,3R)-3-cyclopropyl-2,3-dihydroxypropionate 
• 178248-34-5 methyl (2R,3R)-3-cyclopropyl-2,3-epoxypropionate 
• 179915-14-1 N²-benzyloxycarbonyl-D-isoasparagine 
• 98272-33-4 methyl 3-cyclopropylacrylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 244121-82-2 (R)-3-Benzyloxycarbonylamino-succinamic acid carboxymethyl ester 

Relevant articles and documents

Synthesis of taxoids 5. Synthesis and evaluation of novel water-soluble prodrugs of a 3'-desphenyl-3'-cyclopropyl analogue of docetaxel

A novel 3'-desphenyl-3'-cyclopropyl analogue of docetaxel was synthesized from 10-deacetyl-baccatin III. The cytotoxicity of the new taxoid was evaluated against several human tumor cell lines, and it had ca. 20 times stronger activity against human colon cancer cell lines (WiDr and Colon 320) than that of docetaxel. This taxoid was converted to its water-soluble prodrugs that have 2'-substituted amino acid derivatives with spacer. The prodrugs had good solubility in saline and showed more potent antitumor activity against B 16 melanoma in mice than that of docetaxel.