178271-22-2Relevant academic research and scientific papers
2-SUBSTITUTED BENZOIC ACID DERIVATIVES AS HM74A RECEPTOR AGONISTS
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Page/Page column 38, (2010/02/10)
Therapeutically active anthranilic acid derivatives of Formula (I) wherein R1, R2 and Z are as defined in the specification, processes for the preparation of said derivatives, pharmaceutical formulations containing the active compounds and the use of the compounds in therapy, particularly in the treatment of diseases in which under-activation of the HM74A receptor contributes to the disease or in which activation of the receptor will be beneficial, are disclosed.
Antihyperglycemic activities of cryptolepine analogues: An ethnobotanical lead structure isolated from Cryptolepis sanguinolenta
Bierer, Donald E.,Dubenko, Larisa G.,Zhang, Pingsheng,Lu, Qing,Imbach, Patricia A.,Garofalo, Albert W.,Phuan, Puay-Wah,Fort, Diana M.,Litvak, Joane,Gerber, R. Eric,Sloan, Barbara,Luo, Jian,Cooper, Raymond,Reaven, Gerald M.
, p. 2754 - 2764 (2007/10/03)
Cryptolepine (1) is a rare example of a natural product whose synthesis was reported prior to its isolation from nature. In the previous paper we reported the discovery of cryptolepine's antihyperglycemic properties. As part of a medicinal chemistry progr
