178323-49-4Relevant academic research and scientific papers
New synthesis of isoxazolidines
Malamas, Michael S.,Palka, Cynthia L.
, p. 475 - 478 (1996)
A new synthesis of 5-substituted isoxazolidines was developed by direct isoxazolidine ring formation of allylic hydroxylamines under acidic conditions. The cyclization process is an electrophilic SN1 type reaction. The formed carbocation intermediate is stabilized by electron rich groups (i.e., phenyl). A moiety that mediates oxonium ion formation (i.e., para-methoxy) accelerates the rate of product formation.
