178326-32-4Relevant academic research and scientific papers
Synthesis of epibatidine homologues: Homoepibatidine and bis- homoepibatidine
Malpass,Hemmings,Wallis
, p. 3911 - 3914 (2007/10/03)
Synthetic approaches are described leading to homoepibatidine and bis- homoepibatidine which are based, respectively, on the tropane (8- azabicyclo[3.2.1]octane) and homotropane (9-azabicyclo-[4 2.1]nonane) ring systems. Epoxy- tropanes and -homotropanes (which are readily available from simple cyclic dienes) are convenient precursors for the azabicyclic alkenes needed for the key reductive coupling with pyridine derivatives.
Synthesis of exo- and endo-7,8-epoxyhomotropanes
Justice, David E.,Malpass, John R.
, p. 11947 - 11962 (2007/10/03)
Epoxidation of N-protected homotrop-7-ene (9-azabicyclo[4.2.1]non-7-ene) and 1-substituted derivatives occurs stereoselectively from the exo- (β-) face but a practical alternative approach to the exo- epoxides is based on a serendipitous hydride reduction
