178326-72-2

Usage

Molecular Structure

1H-Pyrido[3,4-b]indole, 2,3,4,9-tetrahydro-2-hydroxy-1-phenyl-, (1S)is a chemical compound with a complex molecular structure.

Classification

It belongs to the class of indole alkaloids.

Natural Origin

It is derived from the natural product voacangine.

Medicinal Properties

It has been studied for its potential medicinal properties.

Dopamine D2 Receptor Agonist

It has the ability to act as a dopamine D2 receptor agonist, which could make it useful in the treatment of certain neurological and psychiatric disorders.

Anti-inflammatory Effects

Research has shown that it may have anti-inflammatory effects.

Antioxidant Effects

It has also been shown to have antioxidant effects, further adding to its potential pharmaceutical applications.

Upstream product

• 213841-84-0 N-benzylidene-N-[2-(3-indolyl)ethyl]amine oxide 
• 4761-34-6 N-Hydroxytryptamine 
• 31731-23-4 3-(2-nitroethyl)indole 

Downstream Products

• 142696-56-8 (S)-1-phenyl-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole 

Relevant academic research and scientific papers

Enantioselective Pictet-Spengler Reaction of Nitrones Derived from Nb-Hydroxytryptamine with Aldehydes Catalyzed by Chiral Br?nsted Acid-Assisted Lewis Acids

The enantioselective Pictet-Spengler reaction catalyzed by chiral binaphthol-derived Br?nsted acid-assisted Lewis acids is demonstrated. The Pictet-Spengler reaction of nitrones, prepared from Nb-hydroxytryptamine with aldehydes, gave the corresponding 1-substituted-2-hydroxytetrahydro-β-carbolines with up to 91% ee.

Chiral Lewis Acid-Mediated Enantioselective Pictet-Spengler Reaction of Nb-Hydroxytryptamine with Aldehydes

The first example of a reagent-controlled enantioselective Pictet-Spengler reaction is demonstrated. Using diisopinocampheylchloroborane as a chiral Lewis acid catalyst, the Pictet-Spengler reaction of Nb-hydroxytryptamine with aldehydes gave the corresponding 2-hydroxytetrahydro-β-carbolines in up to 90% ee. The enantioselective Pictet-Spengler reaction catalyzed by chiral binaphthol-derived Br?nsted acid-assisted Lewis acids, with up to 91% ee, is also demonstrated.

Enantioselective asymmetric Pictet-Spengler reaction catalyzed by diisopinocampheylchloroborane

The first example of a reagent-controlled enantioselective Pictet-Spengler reaction is demonstrated. Employing diisopinocampheylchloroborane as a chiral Lewis acid catalyst, the Pictet-Spengler reaction of N(b)-hydroxytryptamine gave the corresponding 2-h