178357-86-3

Basic information

• Product Name: (2R,5S)-2-(3-Fluoro-4-nitro-benzyl)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazine
• Synonyms: (2R,5S)-2-(3-Fluoro-4-nitro-benzyl)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazine
• CAS NO: 178357-86-3
• Molecular Weight: 337.351
• Mol File: 178357-86-3.mol

Chemical Properties

• CAS DataBase Reference: (2R,5S)-2-(3-Fluoro-4-nitro-benzyl)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,5S)-2-(3-Fluoro-4-nitro-benzyl)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazine(178357-86-3)
• EPA Substance Registry System: (2R,5S)-2-(3-Fluoro-4-nitro-benzyl)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazine(178357-86-3)

Safety Data

• Hazardous Substances Data: 178357-86-3(Hazardous Substances Data)

Upstream product

• 78342-42-4 (S)-2-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine 
• 131858-37-2 4-(bromomethyl)-2-fluoro-1-nitrobenzene 

Downstream Products

• 178735-97-2 3-fluoro-4-nitro-N-[N-(tert-butyloxycarbonyl)-L-tyrosyl]-D-phenylalanine methyl ester 
• 178208-47-4 3-fluoro-4-nitro-N-[N-(tert-butyloxycarbonyl)-N-methyl-L-tyrosyl]-D-phenylalanine methyl ester 
• 178208-46-3 3-fluoro-4-nitro-N-[N-(tert-butyloxycarbonyl)-N-methyl-D-tyrosyl]-D-phenylalanine methyl ester 
• 178208-42-9 (R)-3-fluoro-4-nitrophenylalanine methyl ester 

Relevant articles and documents

Synthesis of (9R,12S)- and (9S,12S)-cycloisodityrosine and their N-methyl derivatives

Full details of the synthesis of (9R,12S)- and (9S,12S)-cycloisodityrosine and their N-methyl derivatives are detailed based on an intramolecular nucleophilic aromatic substitution reaction for formation of the key biaryl ether with 14-membered ring macrocyclization. Their comparison with prior samples and the documentation of a facile C9 epimerization within the natural 9S series are described.