178372-00-4

Upstream product

• 114779-93-0 (+/-)-2-benzylbut-3-enoyl chloride 
• 4783-65-7 N-benzyl-2-piperidinone 
• 100-39-0 benzyl bromide 
• 675-20-7 piperidin-2-one 
• 510728-25-3 (+/-)-N-allyl-N-benzyl-2-benzylbut-3-enamide 
• 510728-26-4 (+/-)-1,3-dibenzyl-3,6-dihydro-1H-pyridin-2-one 
• 114779-92-9 rac-2-benzyl-3-butenoic acid 
• 510728-28-6 (+/-)-1,3-dibenzyl-5-hydroxy-5,6-dihydro-1H-pyridin-2-one 

Relevant academic research and scientific papers

Palladium(II)-Catalyzed Allylic C H Oxidation of Hindered Substrates Featuring Tunable Selectivity Over Extent of Oxidation

The use of Oxone and a palladium(II) catalyst enables the efficient allylic C H oxidation of sterically hindered α-quaternary lactams which are unreactive under known conditions for similar transformations. This simple, safe, and effective system for C H activation allows for unusual tunable selectivity between a two-electron oxidation to the allylic acetates and a four-electron oxidation to the corresponding enals, with the dominant product depending on the presence or absence of water. The versatile synthetic utility of both the allylic acetate and enal products accessible through this methodology is also demonstrated.

Synthesis of functionalized piperidinones

A versatile, stereoselective synthesis of 5-hydroxypiperidinones with substituents at N1, C3, and C6 has been developed. The sequence involves ring-closing metathesis of a diene amide and epoxidation of the resulting alkene, followed by base-mediated elim

Substituted piperidines useful for the treatment of allergic diseases

The present invention relates to novel substituted piperidine derivatives of the formula STR1stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic diseases including: seasonal rhinitis, allergic rhinitis, and sinusitis.

Anticonvulsant and anxiolytic lactam and thiolactam derivatives

This invention relates to lactam and thiolactam derivatives having useful anticonvulsant and anxiolytic activity, pharmaceutical compositions containing these compounds and therapeutic applications using such compositions.