17838-59-4Relevant academic research and scientific papers
Synthesis and assessment of two malonyl dihydrazide derivatives as corrosion inhibitors for carbon steel in acidic media: Experimental and theoretical studies
Alarfaji, Saleh S.,Ali, Ismat H.,Bani-Fwaz, Mutasem Z.,Bedair, Mahmoud A.
, (2021)
Despite the extensive use of carbon steel in all industrial sectors, particularly in the petroleum industry, its low corrosion resistance is an ongoing problem for these industries. In the current work, two malonyl dihydrazide derivatives, namely 2,2’-mal
Synthesis and biological activities of methylenebis-4H-1,2,4-triazole derivatives
Uygun, Yldz,Bayrak, Hacer,Oezkan, Havva
, p. 812 - 823 (2013)
5,5 ′ -Methylenebis(4{phenyl-4H-1,2,4-triazole-3-thiol) (2) was synthesized starting from hydrazinecarbothioamide compound (1). Treatment of compound 2 with ethyl bromoacetate produced diethyl 5,5 ′ -fmethylenebis[(4- phenyl-4H-1,2,4-triazole-5,3-diyl)thio]gdiacetate (3), which was converted to the corresponding diacetohydrazide derivative (4) by treatment with hydrazine hydrate. The reaction of compound 4 with several aldehydes produced the corresponding arylidene hydrazides, 5a{d. Syntheses of Mannich bases 6a{c were carried out by the treatment of compound 2 with several amines in the presence of formaldehyde. (4f[5-(f5-[(4-Amino-2-chlorophenyl)thio]-4- phenyl-4H-1,2,4- Triazol-3-ylgmethyl)-4-phenyl-4H-1,2,4-triazol-3-yl]thiog-3- chlorophenyl)amine (8) was prepared by reduction of 2 nitro groups of 3,3 ′ -methylenebisf5-[(2-chloro-4-nitrophenyl)thio]-4-phenyl-4H-1,2,4- triazoleg (7) that were obtained from the condensation of 2 with 3,4-dichloronitrobenzene. The newly synthesized compounds were screened for their antimicrobial activities; some of them were found to be active towards the test microorganisms as the results demonstrated that the synthesized compounds exhibited a broad spectrum of activity with minimum inhibitory concentration (MIC) values of 31.3{500 μg/mL against gram-positive and gram-negative bacteria, Candia albicans and Saccharomyces cerevisiae. All compounds displayed lower activity in this series against the microorganisms with MIC values of 31.3{500 μg/mL than did the compared control drugs of ampicillin, streptomycin, and uconazole. TUeBITAK.
