178381-04-9Relevant academic research and scientific papers
Catalytic asymmetric synthesis of β-fluoroalkyl-β-amino acids via biomimetic [1,3]-proton shift reaction
Soloshonok, Vadim A.,Kirilenko, Alexander G.,Galushko, Sergey V.,Kukhar, Valery P.
, p. 5063 - 5064 (2007/10/02)
[1,3]-Proton shift reaction of N-benzylenamines 1a-e, derived from β- polyfluoroalkyl-β-ketocarboxylic esters and benzylamine, was catalyzed by (- )-cinchonidine (5-13 mol %) to give good yields (67-89%) of enantiomerically enriched (up to 36% ee) N-benzy
Transamination of Fluorinated β-Keto Carboxylic Esters. A Biomimetic Approach to β-Polyfluoroalkyl-β-amino Acids.
Soloshonok, Vadim A.,Kirilenko, Alexander G.,Kukhar', Valery P.,Resnati, Giuseppe
, p. 3621 - 3624 (2007/10/02)
The base-catalyzed isomerization of N-benzylimines (or enamines) of β-polyfluoroalkyl-β-ketocarboxylic esters cleanly affords the N-benzylidene derivatives of β-polyfluoro-β-aminocarboxylic esters which are hydrolyzed to corresponding amino acids in high overall yields.
