663-35-4

Usage

General Description

Ethyl pentafluoropropionyl acetate is a fluorinated ester

InChI:InChI=1/C7H7F5O3/c1-2-15-5(14)3-4(13)6(8,9)7(10,11)12/h2-3H2,1H3

Upstream product

• 426-65-3 ethyl Pentafluoropropionate 
• 141-78-6 ethyl acetate 
• 378-75-6 perfluoropropionic acid methyl ester 

Downstream Products

• 59-67-6 nicotinic acid 
• 1207089-83-5 2-methyl-4-({3-(pentafluoroethyl)-5-[(2,2,2-trifluoroethyl)thio]-1H-pyrazol-1-yl}methyl)aniline 
• 1207089-81-3 (3-methyl-4-nitrobenzyl)-3-(pentafluoroethyl)-5-[(trifluoromethyl)thio]-1H-pyrazole 
• 1448776-35-9 N-phenyl-3-difluoromethyl-5-pentafluoroethyl-4-pyrazolecarboxylic acid ethyl ester 
• 1207089-84-6 1-(3-methyl-4-nitrobenzyl)-3-(pentafluoroethyl)-5-[(2,2,2-trifluoroethyl)thio]-1H-pyrazole 
• 1207089-80-2 1-(3-methyl-4-nitrobenzyl)-3-(pentafluoroethyl)-1H-pyrazole-5-thiol 
• 1207089-77-7 1-(3-methyl-4-nitrobenzyl)-3-(pentafluoroethyl)-1H-pyrazol-5-ol 
• 178381-04-9 4,4,5,5,5-Pentafluoro-3-{[1-phenyl-meth-(E)-ylidene]-amino}-pentanoic acid ethyl ester 
• 150618-25-0 ethyl (Z)-3-benzylamino-4,4,5,5,5-pentafluoropent-2-enoate 

Relevant academic research and scientific papers

IMPROVED PROCESS FOR PREPARING SUBSTITUTED CROTONIC ACIDS

A process to prepare a compound of Formula (I) wherein R3, R4 and R5 are each selected independently from hydrogen, halogen, alkyl, alkenyl, alkynyl, alkoxyl, and wherein the alkyl, alkenyl, alkynyl, and alkoxyl may be optionally substituted with one or more halogen, alkyl, alkenyl, alkynyl, and alkoxyl.

Studies on a three-step preparation of β-fluoroalkyl acrylates from fluoroacetic esters

β-Fluoroalkyl-acrylic esters are valuable building blocks for the synthesis of organofluorine compounds. Although the preparation of several β-fluoroalkyl-acrylates is known, a general and straightforward lab-scale methodology for the preparation of multigram amounts of these compounds from fluoroacetic esters is not available, and the related chemistry has not been investigated in detail. We now describe an optimized three-step protocol relying on: (1) Claisen-type condensation of fluoroacetic esters with ethyl acetate, using LDA as base; (2) reduction of the resulting γ-fluoro-β-keto esters by NaBH4, using toluene or benzene as solvents; (3) P2O5-promoted dehydration of the intermediate γ-fluoro-β-hydroxy esters. The methodology affords preparatively useful yields of the target compounds incorporating only fluorine atoms (CF3, CHF2, C2F5), whereas the γ-halodifluoromethyl (CClF2, CBrF2, CIF2) acrylates could not be obtained in analytically pure form from the dehydration step.

3-perfluoroalkyl-5-hydroxyisoxazoles

A novel compound useful as an intermediate for synthesizing pesticides and medicine of the formula: STR1 in which: R is perfluoroalkyl, R1 is hydrogen, alkyl or optionally substituted phenyl, or a salt thereof.

THE SYNTHESIS OF OPTICALLY ACTIVE BUILDING BLOCKS CARRYING AN α,α-DIHALOGENO-β,β,β-TRIFLUOROETHYL GROUP

Optically active molecules with α,α-dihalogeno-β,β,β-trifluoroethyl groups were prepared by the microbial hydrolysis of the corresponding esters.