178381-06-1

Basic information

• Product Name: 4,4-Difluoro-3-{[1-phenyl-meth-(E)-ylidene]-amino}-butyric acid ethyl ester
• Synonyms: 4,4-Difluoro-3-{[1-phenyl-meth-(E)-ylidene]-amino}-butyric acid ethyl ester
• CAS NO: 178381-06-1
• Molecular Weight: 255.264
• Mol File: 178381-06-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4,4-Difluoro-3-{[1-phenyl-meth-(E)-ylidene]-amino}-butyric acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4-Difluoro-3-{[1-phenyl-meth-(E)-ylidene]-amino}-butyric acid ethyl ester(178381-06-1)
• EPA Substance Registry System: 4,4-Difluoro-3-{[1-phenyl-meth-(E)-ylidene]-amino}-butyric acid ethyl ester(178381-06-1)

Safety Data

• Hazardous Substances Data: 178381-06-1(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 150618-33-0 ethyl 4,4-difluoro-3-benzylamino-2-butenoate 
• 352-24-9 ethyl 4,4-difluoro-3-oxobutyrate 

Relevant articles and documents

Transamination of Fluorinated β-Keto Carboxylic Esters. A Biomimetic Approach to β-Polyfluoroalkyl-β-amino Acids.

The base-catalyzed isomerization of N-benzylimines (or enamines) of β-polyfluoroalkyl-β-ketocarboxylic esters cleanly affords the N-benzylidene derivatives of β-polyfluoro-β-aminocarboxylic esters which are hydrolyzed to corresponding amino acids in high overall yields.