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352-24-9

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352-24-9 Usage

Uses

Different sources of media describe the Uses of 352-24-9 differently. You can refer to the following data:
1. Ethyl 4,4-difluoro-3-oxobutanoate is an intermediate used for the synthesis of pharmaceuticals such as potassium channel activators and β-alanine derived GABA-T antagonists.
2. Ethyl 4,4-Difluoroacetoacetate is an intermediate used for the synthesis of pharmaceuticals such as potassium channel activators and β-alanine derived GABA-T antagonists.

Check Digit Verification of cas no

The CAS Registry Mumber 352-24-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,5 and 2 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 352-24:
(5*3)+(4*5)+(3*2)+(2*2)+(1*4)=49
49 % 10 = 9
So 352-24-9 is a valid CAS Registry Number.
InChI:InChI=1/C6H8F2O3/c1-2-11-5(10)3-4(9)6(7)8/h6H,2-3H2,1H3

352-24-9 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (E1018)  Ethyl 4,4-Difluoroacetoacetate  >96.0%(GC)

  • 352-24-9

  • 5g

  • 460.00CNY

  • Detail
  • TCI America

  • (E1018)  Ethyl 4,4-Difluoroacetoacetate  >96.0%(GC)

  • 352-24-9

  • 25g

  • 1,580.00CNY

  • Detail
  • Alfa Aesar

  • (H31922)  Ethyl 4,4-difluoroacetoacetate, 98%   

  • 352-24-9

  • 1g

  • 421.0CNY

  • Detail
  • Alfa Aesar

  • (H31922)  Ethyl 4,4-difluoroacetoacetate, 98%   

  • 352-24-9

  • 5g

  • 1394.0CNY

  • Detail

352-24-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl 4,4-difluoro-3-oxobutanoate

1.2 Other means of identification

Product number -
Other names Butanoic acid,4,4-difluoro-3-oxo-,ethyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:352-24-9 SDS

352-24-9Relevant articles and documents

Synthesis of analogs of farnesyl diphosphate

Dolence,Poulter

, p. 119 - 130 (1996)

Syntheses of analogs of farnesyl diphosphate (FPP) bearing substitutions at C3 are described. The mono-, di-, and trifluoromethylFPP derivatives were prepared by alkylation of appropriately substituted acetoacetates with geranyl bromide, followed by decarboxylation to obtain fluorinated ketones and a Wittig condensation to give the farnesyl skeleton. A similar sequence was used to synthesize 13-desmethylFPP.

-

McBee et al.

, p. 3152 (1953)

-

Cu-Mediated Expeditious Annulation of Alkyl 3-Aminoacrylates with Aryldiazonium Salts: Access to Alkyl N2-Aryl 1,2,3-Triazole-carboxylates for Druglike Molecular Synthesis

Liu, Hao-Nan,Cao, Hao-Qiang,Cheung, Chi Wai,Ma, Jun-An

supporting information, p. 1396 - 1401 (2020/02/22)

Alkyl N-aryl 1,2,3-triazole-carboxylates are important molecules or intermediates in medicinal chemistry, but the synthesis of N2-aryl counterparts remains elusive. Herein, we describe a Cu-mediated annulation reaction of alkyl 3-aminoacrylates with aryldiazonium salts, both of which are readily available substrates. Furthermore, alkyl 2-aminoacrylates are also viable substrates. Diverse alkyl N2-aryl 1,2,3-triazole-carboxylates and their analogues can be rapidly prepared under mild conditions. Especially, this protocol allows one to access several druglike variants of carbonic anhydrase inhibitors and celecoxib.

A laminated material for catalytic synthesis of difluoro-acetyl-acetic acid ethyl ester

-

Paragraph 0031-0033, (2017/08/15)

The invention discloses a method for synthesizing ethyl 4,4-difluoroacetoacetate in a catalyzed mode through layered materials. The method includes the following steps: 1, a divalent and trivalent metal salt solution and a sodium hydroxide and sodium carbonate mixed solution are rapidly mixed to prepare multielement hydrotalcite, the multielement hydrotalcite is roasted to be added into a fluoride-salt saturation aqueous solution, the mixture is stirred, filtered, washed and dried to be roasted under the nitrogen condition, and catalysts are obtained; 2, ethyl acetate, ethyl difluoroacetate and the catalysts are added into a four-opening flask, an ethyl alcohol and ethyl acetate mixture is evaporated after temperature rising, stirring and reacting are carried out, cooling is carried out, catalysts are filtered and recycled, filtrate is acidized, cooled and filtered, and pressure reduction rectification is carried out on the filtrate to obtain the ethyl 4,4-difluoroacetoacetate; 3, the recycled catalysts are sufficiently washed through solvents and roasted to be added into a fluoride-salt saturation aqueous solution, the mixture is stirred, filtered, washed and dried to be roasted under the nitrogen condition, and the catalysts are regenerated. The method has the advantages that the yield is high, the catalysts can be recycled, and the method is safe and environmentally friendly.

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