178384-83-3Relevant academic research and scientific papers
Tropone-substituted phenyloxazolidinone antibacterial agents
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, (2008/06/13)
A novel class of phenyloxazolidinone antibacterial agents which have, as their salient structural feature, an appended substituted tropone moiety, are described. Intermediates and processes for the preparation of these antibiotics are also disclosed. These compounds are useful antibacterial agents to eradicate or control susceptible organisms. STR1 wherein R4 is oxygen substituted heptatrienyl and R1, R2, and R3 are as defined herein.
Synthesis and antibacterial activity of new tropone-substituted phenyloxazolidinone antibacterial agents. 1. Identification of leads and importance of the tropone substitution pattern
Barbachyn, Michael R.,Toops, Dana S.,Ulanowicz, Debra A.,Grega, Kevin C.,Brickner, Steven J.,Ford, Charles W.,Zurenko, Gary E.,Hamel, Judith C.,Schaadt, Ronda D.,Stapert, Douglas,Yagi, Betty H.,Buysse, Jerry M.,Demyan, William F.,Kilburn, James O.,Glickman, Suzanne E.
, p. 1003 - 1008 (2007/10/03)
Incorporation of a substituted tropone moiety into the para position of suitably functionalized 3-phenyl-2-oxazolidinones affords novel and potent antibacterial agents. The effect of the tropone regioisomer and its attendant substituents on antibacterial activity is discussed. Analogues such as 11c and 13b display in vitro and in vivo activity approaching that of the current clinical benchmark, vancomycin.
