115017-01-1

Upstream product

• 367925-77-7 5-acetamidomethyl-3-phenyl-1,3-oxazolidin-2-one 
• 540-37-4 p-aminoiodobenzene 
• 108-24-7 acetic anhydride 

Downstream Products

• 178384-83-3 (+/-)-N-[[3-[4-(4-methoxy-3-oxo-1,4,6-cycloheptatrien-1-yl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 
• 128311-86-4 (l)-N-[3-(4-(4'-Pyridyl)phenyl)-2-oxooxazolidin-5-ylmethyl]acetamide 
• 123672-51-5 (l)-N-[3-[4-(E-1-methyl-2-carbomethoxyethenyl)phenyl]-2-oxooxazolidin-5-ylmethyl]acetamide 
• 178245-30-2 (+/-)-N-[[3-[4-(4-methoxy-5-oxo-1,3,6-cycloheptatrien-1-yl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 

Relevant academic research and scientific papers

Linezolid impurity 1 and preparation method thereof

The invention discloses a linezolid impurity 1 as shown in a formula I and a preparation method thereof. The preparation method comprises the following steps of: 1, adding 4-iodoaniline, S-phthalimide glycidyl, isopropanol and water, and carrying out a reaction on the 4-iodoaniline, the S-phthalimide glycidyl, the isopropanol and the water; 2, adding an intermediate 3 and 1, 4-dioxane, adding carbonyl diimidazole, and carrying out a reaction on the intermediate 3 and the 1, 4-dioxane; 3, adding an intermediate 4 and methanol, adding hydrazine hydrate, and performing a reaction on the intermediate 4; and 4, adding an intermediate 5 and 1, 4-dioxane, adding cesium carbonate and cuprous iodide at room temperature, and reacting under the protection of inert gas to obtain the product. The linezolid impurity 1 prepared by the method is good in purity and high in yield.

Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents

Novel aminomethyloxooxazolidinyl arylbenzene derivatives, wherein the aryl includes the phenyl, substituted phenyl, pyridyl, and substituted pyridyl groups, such as (l)-N-{3-[4-(4'-pyridyl)phenyl]-2-oxooxazolidin-5-ylmethyl{acetamide, possess useful antib

Aminomethyl oxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents

Aminomethyl oxooxazolidinyl ethenylbenzene derivatives, including the nitriles, sulfoxides, acetamides and nitro compounds, such as l-N-[3-[4-(E-1-methyl-2-cyanoethenyl)phenyl]-2-oxooxazolidin-5-ylmethyl]acetamide, possess useful antibacterial activity.

Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents

Novel aminomethyl oxooxazolidinyl benzene derivatives, including the sulfides, sulfoxides, sulfones and sulfonamides, such as (l)-N-[3-[4-(methylsulfinyl)phenyl]-2-oxooxazolidin-5-ylmethyl]acetamide, possess useful antibacterial activity.