178432-30-9Relevant academic research and scientific papers
Regulating the Rate of Molecular Self-Assembly for Targeting Cancer Cells
Zhou, Jie,Du, Xuewen,Xu, Bing
, p. 5770 - 5775 (2016)
Besides tight and specific ligand-receptor interactions, the rate regulation of the formation of molecular assemblies is one of fundamental features of cells. But the latter receives little exploration for developing anticancer therapeutics. Here we show
Enzymatic Self-Assembly Confers Exceptionally Strong Synergism with NF-κB Targeting for Selective Necroptosis of Cancer Cells
Zhou, Jie,Du, Xuewen,Chen, Xiaoyi,Wang, Jiaqing,Zhou, Ning,Wu, Difei,Xu, Bing
, p. 2301 - 2308 (2018)
As a promising molecular process for selectively inhibiting cancer cells without inducing acquired drug resistance, enzyme-instructed self-assembly (EISA) usually requires relatively high dosages. Despite its discovery 30 years ago, the translation of the
Enzyme-Instructed Assembly and Disassembly Processes for Targeting Downregulation in Cancer Cells
Feng, Zhaoqianqi,Wang, Huaimin,Zhou, Rong,Li, Jie,Xu, Bing
, p. 3950 - 3953 (2017)
Cancer cells differ from normal cells in both gain of functions (i.e., upregulation) and loss of functions (i.e., downregulation). While it is common to suppress gain of function for chemotherapy, it remains challenging to target downregulation in cancer cells. Here we show the combination of enzyme-instructed assembly and disassembly to target downregulation in cancer cells by designing peptidic precursors as the substrates of both carboxylesterases (CESs) and alkaline phosphatases (ALPs). The precursors turn into self-assembling molecules to form nanofibrils upon dephosphorylation by ALP, but CES-catalyzed cleavage of the ester bond on the molecules results in disassembly of the nanofibrils. The precursors selectively inhibit the cancer cells that downregulate CES (e.g., OVSAHO) but are innocuous to a hepatocyte that overexpresses CES (HepG2), while the two cell lines exhibit comparable ALP activities. This work illustrates a potential approach for the development of chemotherapy via targeting downregulation (or loss of functions) in cancer cells.
Enzymatically Forming Intranuclear Peptide Assemblies for Selectively Killing Human Induced Pluripotent Stem Cells
He, Hongjian,Liu, Shuang,Lu, Shijiang,Shy, Adrianna N.,Xu, Bing,Yi, Meihui,Zhang, Qiuxin
supporting information, p. 15852 - 15862 (2021/10/02)
Tumorigenic risk of undifferentiated human induced pluripotent stem cells (iPSCs), being a major obstacle for clinical application of iPSCs, requires novel approaches for selectively eliminating undifferentiated iPSCs. Here, we show that an l-phosphopenta
Enzyme Instructed Self-assembly of Naphthalimide-dipeptide: Spontaneous Transformation from Nanosphere to Nanotubular Structures that Induces Hydrogelation
Chakravarthy, Rajan Deepan,Lin, Hsin-Chieh,Mohammed, Mohiuddin
, (2020/08/03)
Understanding the structure-morphology relationships of self-assembled nanostructures is crucial for developing materials with the desired chemical and biological functions. Here, phosphate-based naphthalimide (NI) derivatives have been developed for the
Paclitaxel anticancer nano drug obtained by in-situ formation
-
, (2018/06/14)
The invention relates to a paclitaxel anticancer nano drug obtained by in-situ formation. The drug takes paclitaxel and an amphipathic compound having a PY polypeptide sequence through covalent connection as a prodrug, under catalysis of alkaline phosphat
An in situ Dynamic Continuum of Supramolecular Phosphoglycopeptides Enables Formation of 3D Cell Spheroids
Wang, Huaimin,Shi, Junfeng,Feng, Zhaoqianqi,Zhou, Rong,Wang, Shiyu,Rodal, Avital A.,Xu, Bing
supporting information, p. 16297 - 16301 (2017/11/27)
Higher-order assemblies of proteins, with a structural and dynamic continuum, is an important concept in biology, but these insights have yet to be applied in designing biomaterials. Dynamic assemblies of supramolecular phosphoglycopeptides (sPGPs) transf
Enzyme-instructed self-assembly with photo-responses for the photo-regulation of cancer cells
Zhou, Zhengquan,Xie, Xian,Yi, Qikun,Yin, Wencui,Kadi, Adnan A.,Li, Jinbo,Zhang, Yan
supporting information, p. 6892 - 6895 (2017/09/01)
Using a short peptide precursor modified by the biaryltetrazole with intramolecular photo-click reactivity, we realized the photo-regulation of the pericellular nanofibers formed by the enzyme-instructed self-assembly on the cell membrane. Upon light irra
Enzyme-Instructed Self-Assembly of Small d -Peptides as a Multiple-Step Process for Selectively Killing Cancer Cells
Zhou, Jie,Du, Xuewen,Yamagata, Natsuko,Xu, Bing
, p. 3813 - 3823 (2016/04/09)
Selective inhibition of cancer cells remains a challenge in chemotherapy. Here we report the molecular and cellular validation of enzyme-instructed self-assembly (EISA) as a multiple step process for selectively killing cancer cells that overexpress alkal
A general and convenient synthesis of novel phosphotyrosine mimetics
Szardenings, Anna Katrin,Gordeev, Mikhail F.,Patel, Dinesh V.
, p. 3635 - 3638 (2007/10/03)
A simple and general procedure for preparation of various phosphotyrosine mimetics from the corresponding phenolic precursors is described. In situ silylation of phenol acids followed by treatment with Et3N/CBr4/HP(O)(OEt)2 provides diethyl phosphate intermediates (36-96%), which can be cleanly deprotected in quantitative yields upon treatment with BSTFA/TMSI to afford novel phosphotyrosine mimetics.
