178432-54-7

Upstream product

• 263720-91-8 diethyl 5-([(1-tert-butyl)-1,1-dimethylsilyl]oxymethyl)-2,8-decadiynedioate 
• 178432-52-5 1,10-bis(tetrahydropyranyloxy)-5-hydroxymethyl-2,8-decadiyne 
• 263720-92-9 1,10-dihydroxy-5-tert-butyldimethylsiloxymethyl-2,8-decadiyne 
• 263720-90-7 1-(tert-butyl)-1,1-dimethylsilyl [2-(2-propynyl)-5-hexynyl]ether 
• 263720-87-2 methyl 2-(2-propynyl)-5-hexynoate 
• 263720-89-4 2-(2-propynyl)-5-hexyn-1-ol 

Downstream Products

• 178432-55-8 1,10-dibromo-5-(O-diethylstilbestryl-[O-methyl] phenoxymethyl)-2,8-decadiyne 

Relevant academic research and scientific papers

Target directed enediyne prodrugs: Cytotoxic estrogen conjugates

Enediyne estrogen conjugates have been prepared from readily available precursors. Enediyne 12 causes significant DNA strand scission at 10-3 M, and has demonstrated cytotoxicity against the ER rich MCF-7 human breast cancer cell line.