1784426-29-4

Basic information

• Product Name: 7-bromo-4,4-dimethyl-3,4-dihydroisoquinolin-1(2H)-one
• CAS NO: 1784426-29-4
• Molecular Weight: 254.126
• Mol File: 1784426-29-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 7-bromo-4,4-dimethyl-3,4-dihydroisoquinolin-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-bromo-4,4-dimethyl-3,4-dihydroisoquinolin-1(2H)-one(1784426-29-4)
• EPA Substance Registry System: 7-bromo-4,4-dimethyl-3,4-dihydroisoquinolin-1(2H)-one(1784426-29-4)

Safety Data

• Hazardous Substances Data: 1784426-29-4(Hazardous Substances Data)

Upstream product

• 264602-70-2 2-(4-bromophenyl)-2-methylpropan-1-amine 
• 101184-73-0 2-(4-bromophenyl)-2-methylpropanenitrile 

Relevant articles and documents

Protein arginine methyltransferase 5 (PRMT5) inhibitor, pharmaceutical products thereof, and methods thereof

The present invention provides a PRMT5 inhibitor of formula (I); R1 is a non-hydrogen monovalent group; W is a direct bond or-NH-; T, U and V are independently from each other selected from C and N; R2 is H or halogen; m is 1 or 2; X is carbon, nitrogen or oxygen; Y is C or N; Z is a direct bond or carbon; R3 is H, a non-hydrogen monovalent group, an oxo group, a divalent spiro-forming group or adivalent bridge-forming group; and n is 1 or 2, and represents a single or double bond. The present invention also provides pharmaceutical products comprising the PRMT5 inhibitor and use thereof in the treatment of proliferative disorders such as cancer, metabolic disorders, hematological disorders, autoimmune diseases and inflammatory diseases.