178446-63-4

Basic information

• Product Name: 5-[(tert-butoxycarbonyl)amino]benzene-1,3-dicarboxylic acid
• CAS NO: 178446-63-4
• Molecular Formula: C₁₃H₁₅NO₆
• Molecular Weight: 281.2613
• Mol File: 178446-63-4.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 440.1°C at 760 mmHg
• Flash Point: 220°C
• Density: 1.382g/cm³
• Vapor Pressure: 1.6E-08mmHg at 25°C
• Refractive Index: 1.603
• CAS DataBase Reference: 5-[(tert-butoxycarbonyl)amino]benzene-1,3-dicarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[(tert-butoxycarbonyl)amino]benzene-1,3-dicarboxylic acid(178446-63-4)
• EPA Substance Registry System: 5-[(tert-butoxycarbonyl)amino]benzene-1,3-dicarboxylic acid(178446-63-4)

Safety Data

• Hazardous Substances Data: 178446-63-4(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 99-27-4 dimethyl 5-aminoisophthalate 
• 99-31-0 5-aminoisophthalic acid 

Downstream Products

• 380607-61-4 5-N-(tert-butyloxycarbonyl)aminoisophthalate-1,3-bis-O-(2,3,5,6-tetrafluorophenyl) ester 
• 940005-72-1 (3,5-bis(prop-2-ynylcarbamoyl)phenyl)-carbamic acid tert-butyl ester 
• 1135615-28-9 C₂₉H₂₅N₃O₄ 
• 1236075-35-6 N,N'-bis(N-(tert-butyloxycarbonyl)-N-(8-amino-3,6-dioxaoctanylamino))-5-(N-tert-butyloxycarbonyl)aminoisophthalamide 
• 1404300-69-1 (5-(methylamino)-1,3-phenylene)dimethanol 
• 178446-64-5 (5-tert-butoxycarbonylamino)isophthalic acid bis(2,5-dioxopyrrolidin-1-yl) ester 
• 363602-32-8 BOC-[(L)-Pro-(5-aminoisophthalic acid)-(OBn)]3-OAll 
• 363602-33-9 5-[((S)-1-{3-Benzyloxycarbonyl-5-[((S)-1-{3-benzyloxycarbonyl-5-[((S)-pyrrolidine-2-carbonyl)-amino]-benzoyl}-pyrrolidine-2-carbonyl)-amino]-benzoyl}-pyrrolidine-2-carbonyl)-amino]-isophthalic acid monobenzyl ester 
• 363602-37-3 cyclo-[(L)-Pro-AIA(Bn)]3 
• 363602-31-7 BOC-(L)-Pro-(5-aminoisophthalic acid)-(OBn)-OAll 
• 363602-35-1 5-[(tert-butyloxycarbonyl)amino]-isophthalic acid mono allyl mono benzyl ester 
• 363602-30-6 5-amino-isophthalic acid 1-allyl ester 3-benzyl ester 
• 363602-46-4 BOC-{(L)-Pro-(5-aminoisophthalic acid)-[(L)-Glu(OBn)-OiPr]}2-OAll 
• 363602-36-2 BOC-[(L)-Pro-(5-aminoisophthalic acid)-(OBn)]2-OAll 

Relevant articles and documents

Protection strategies for directionally-controlled synthesis of previously inaccessible metal-organic polyhedra (MOPs): The cases of carboxylate: The amino-functionalised Rh(ii)-MOPs

Herein we report that strategic use of protecting groups in coordination reactions enables directional inhibition that leads to synthesis of highly functionalised metal-organic polyhedra (MOPs), rather than of the extended coordination networks. Using this approach, we functionalised two new porous cuboctahedral Rh(ii)-based MOPs with 24 peripheral carboxylic acid groups or 24 peripheral amino groups.

BIOPROBES FOR LYSYL OXIDASES AND USES THEREOF

The present invention relates to novel bioprobes which are capable of binding to certain amine oxidase enzymes. These bioprobes are useful in methods of detecting and determining the concentration of certain amine oxidase enzymes in a sample as well as in methods for the quantitative assessment of inhibition of certain amine oxidases.

Facile synthesis and antitumor activity of novel N(9) methylated AHMA analogs

A facile synthesis of novel antitumor N(9)-methyl-3-(9-acridinylamino)-5- hydroxymethylaniline (AHMA) derivatives is described. Boc protection of aminobenzoic acids followed by LiAlH4 reduction yielded novel methylaminobenzyl alcohol reactants. Their interaction with 9-chloroacridine provides N(9)-methylated AHMA derivatives for biological screening. A preliminary anti-proliferative assay against seven cancer cell lines identified compounds with low μM IC50 values. The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.