178446-74-7Relevant academic research and scientific papers
Regiocontrolled benzannulation of diaryl(gem-dichlorocyclopropyl)methanols for the synthesis of unsymmetrically substituted α-arylnaphthalenes: Application to total synthesis of natural lignan lactones
Nishii, Yoshinori,Yoshida, Taichi,Asano, Hirofumi,Wakasugi, Kazunori,Morita, Jun-Ichi,Aso, Yoshifumi,Yoshida, Eri,Motoyoshiya, Jiro,Aoyama, Hiromu,Tanabe, Yoo
, p. 2667 - 2678 (2007/10/03)
(Chemical Equation Presented) An efficient synthesis of highly substituted α-arylnaphthalene analogues has been developed utilizing Lewis acid-promoted regiocontrolled benzannulation of aryl(aryl′)-2,2- dichlorocyclopropylmethanols (aryl ≠ aryl′; abbrevia
Novel selective PDE IV inhibitors as antiasthmatic agents. Synthesis and biological activities of a series of 1-aryl-2,3- bis(hydroxymethyl)naphthalene lignans
Iwasaki, Tameo,Kondo, Kazuhiko,Kuroda, Tooru,Moritani, Yasunori,Yamagata, Shinsuke,Sugiura, Masaki,Kikkawa, Hideo,Kaminuma, Osamu,Ikezawa, Katsuo
, p. 2696 - 2704 (2007/10/03)
A series of 1-aryl-2,3-bis(hydroxymethyl)naphthalene lignans have been synthesized and evaluated for their ability to selectively inhibit PDE IV isolated from guinea pig. Replacement of the 1-phenyl ring by a pyridone ring led to marked improvement of the
