178449-64-4Relevant academic research and scientific papers
Synthesis and biological activity of some 3-methyl/ethoxycarbonyl-6-arylimidazo[2,1-b]thiazoles and their 5-bromo/ 5-formyl derivatives
Khazi,Koti,Gadad,Mahajanshetti,Shivakumar,Akki
, p. 393 - 398 (2007/10/03)
Facile reaction of arylacylbromide 1 with 2-amino-4-methylthiazole 2 and its hindered reaction with 2-amino-4-ethoxycarbonylthiazole 3 during the synthesis of 3-methyl/ethoxycarbonyl-6-arylimidazo[2,1-b]thiazoles 8/9 are explained on the basis of electron
Potential antitumor agents. 24. Synthesis and pharmacological behavior of imidazo[2,1-b]thiazole guanylhydrazones bearing at least one chlorine
Andreani, Aldo,Rambaldi, Mirella,Leoni, Alberto,Locatelli, Alessandra,Bossa, Rosaria,Fraccari, Alessandra,Galatulas, Iraklis,Salvatore, Gaetano
, p. 2852 - 2855 (2007/10/03)
In connection with a previous research dealing with the antitumor activity of imidazo[2,1-b]-thiazole guanylhydrazones, this paper reports the synthesis of new derivatives which were tested for antitumor and positive inotropic activity. In most cases the cytotoxic data from the in vitro experiments (HeLa) were in agreement with the antitumor data in vivo (Ehrlich). The active compounds bear a phenyl ring at the 6 position. On the other hand, the most active cardiotonic agents were devoid of the phenyl ring.
