17847-44-8

Basic information

• Product Name: Methanesulfonamide, N-(3,4-dichlorophenyl)-
• CAS NO: 17847-44-8
• Molecular Formula: C7H7Cl2NO2S
• Molecular Weight: 240.11
• Mol File: 17847-44-8.mol

Chemical Properties

• CAS DataBase Reference: Methanesulfonamide, N-(3,4-dichlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanesulfonamide, N-(3,4-dichlorophenyl)-(17847-44-8)
• EPA Substance Registry System: Methanesulfonamide, N-(3,4-dichlorophenyl)-(17847-44-8)

Safety Data

• Hazardous Substances Data: 17847-44-8(Hazardous Substances Data)

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 95-76-1 m,p-dichloroaniline 

Downstream Products

• 71270-33-2 N-(3-Cyano-propyl)-N-(3,4-dichloro-phenyl)-methanesulfonamide 
• 71273-59-1 N-Cyanomethyl-N-(3,4-dichloro-phenyl)-methanesulfonamide 
• 71270-76-3 N-(3,4-Dichloro-phenyl)-N-(2-oxo-propyl)-methanesulfonamide 
• 71273-61-5 2-[(3,4-Dichloro-phenyl)-methanesulfonyl-amino]-thioacetamide 
• 77166-74-6 N-(3,4-Dichloro-phenyl)-N-[2-hydroxy-3-(4-phenyl-piperazin-1-yl)-propyl]-methanesulfonamide 
• 606-42-8 5,6-dichloro-quinoline 
• 40635-11-8 6.7-Dichlor-chinolin 
• 77167-17-0 N-(3,4-Dichloro-phenyl)-N-oxiranylmethyl-methanesulfonamide 
• 71274-15-2 2-[(3,4-Dichloro-phenyl)-methanesulfonyl-amino]-propionic acid 
• 71381-42-5 2-[(3,4-Dichloro-phenyl)-methanesulfonyl-amino]-N,N-diethyl-acetamide 
• 22736-62-5 N-(3,4-Dichloro-phenyl)-N-(1,1,2,2-tetrachloro-2-fluoro-ethylsulfanyl)-methanesulfonamide 

Relevant articles and documents

Soft-Hard Acid/Base-Controlled, Oxidative, N-Selective Arylation of Sulfonanilides via a Nitrenium Ion

In iodine(III)-catalyzed, dehydrogenative arylations of sulfonanilides, the functionalization of C-C bonds is preferred over the functionalization of C-N bonds. Herein, an unprecedented N-selective arylation of sulfonanilides using soft-hard acid-base (SHAB) control by a nitrenium ion over a carbenium ion is reported. Treatment of sulfonanilides with iodine(III) led to the formation of nitrenium ions (soft), which preferentially react with biphenyls (soft) over bimesityl (hard) to generate C-N bonds. The iodine(III) was generated in situ by using PhI and mCPBA at room temperature.

A practical route to quinolines from anilines

A practical route to quinoline from anilines through acid-mediated cyclization of 3-(N-aryl-N-sulfonylamino)propionaldehydes has been developed. Treatment of the cyclization products, dihydroquinoline intermediates with KOH in DMSO leads to substituted quinolines.