17850-83-8Relevant academic research and scientific papers
Simple o-Quinodimethane Route to (+/-)-4-Demethoxydaunomycinone
Kerdesky, Francis A.,Ardecky, Robert J.,Lakshmikantham, M. V.,Cava, Michael P.
, p. 1992 - 1996 (1981)
The anthracycline antibiotics daunorubicin and adriamycin are important clinically useful drugs in the treatment of a number of human cancers.The structurally simplified synthetic analogues 4-demethoxydaunorubicin and 4-demethoxyadriamycin show much clinical promise.The synthesis of the corresponding aglycon (+/-)-4-demethoxydaunomycinone from the inexpensive dye intermediate quinizarin, utilizing o-quinodimethane intermediates, is discussed.
