178532-48-4Relevant academic research and scientific papers
An enantiomerically encriched (α-phenylselenoalkyl)magnesium compound
Klute, Wolfgang,Krueger, Michael,Hoffmann, Reinhard W.
, p. 633 - 638 (2007/10/03)
α-Selenoalkyl Grignard reagents 2 are chiral. On reaction with the magnesium chelate 3a of α-benzyloxypropionaldehyde they show significant degrees of kinetic resolution, especially when the reactions are run in CH2Cl2. Under these conditions, racemic 2 was resolved by reaction with 0.59 equivalents of 3a at temperatures below -20°C. The remaining 2 had an enantiomer enrichment of 80-86% e.e. (as found by trapping). Hence, 2 has a considerably higher configurational stability than its lithium counterpart 1. VCH Veriagsgesdschaft mbH, 1996.
