178552-19-7

Upstream product

• 178552-17-5 N-(3-trifluoromethyl-4-methoxycarbonyl-5-isoxazolyl)benzenesulfonamide 
• 98-09-9 benzenesulfonyl chloride 
• 178552-18-6 5-Benzenesulfonylamino-3-trifluoromethyl-isoxazole-4-carboxylic acid 

Relevant academic research and scientific papers

A facile synthesis of 5-amino-3-trifluoromethyl-4- methoxycarbonylisoxazole

The title compound was synthesized in 3 steps from readily available cyanoacetate and TFAA. The ester group allowed access to other functionalized isoxazole derivatives.

N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin

N-(4-halo-isoxazolyl)sulfonamides and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, N-(4-halo-3-isoxazolyl)sulfonamides and N-(4-halo-5-isoxazolyl)benzenesulfonamides and methods for inhibiting the binding of an endothelin peptide to an endothelin receptor or increasing the activity of endothelin peptides by contacting the receptor with a sulfonamide are provided. Methods for treating endothelin-mediated disorders by administering effective amounts of one or more of these sulfonamides or prodrugs thereof that inhibit or increase the activity of endothelin are also provided.