178553-80-5

Upstream product

• 68163-71-3 4,5-bis(4-fluorophenyl)-1H-imidazole 
• 74-88-4 methyl iodide 

Downstream Products

• 81659-38-3 α,α-bis(trifluoromethyl)-4,5-bis(4-fluorophenyl)-1-methyl-1H-imidazole-2-methanamine 
• 139981-69-4 4-Fluoro-N-[2-(4-fluoro-phenyl)-3-methyl-5,5-bis-trifluoromethyl-3,5-dihydro-imidazol-(4Z)-ylidene]-benzamide 

Relevant academic research and scientific papers

A facile synthesis of 4,4-bis(trifluoromethyl)-imidazolinesvia a novel oxidative imidazole rearrangement

Oxidation of imidazole (1) with singlet oxygen or m-chloroperbenzoic acid affords novel 4,4-bis(trifluoromethyl)imidazolines in high yield via a unique oxidative ring opening and subsequent acid catalyzed dehydrocyclization.