81659-38-3

Upstream product

• 17599-55-2 [1,1-di(trifluoromethyl)methyleneamino]-trimethylsilane 
• 178553-80-5 4,5-Bis-(4-fluoro-phenyl)-1-methyl-1H-imidazole 
• 68163-71-3 4,5-bis(4-fluorophenyl)-1H-imidazole 

Downstream Products

• 189871-23-6 [(S)-2-(4-Fluoro-phenyl)-3-methyl-5,5-bis-trifluoromethyl-4,5-dihydro-3H-imidazol-4-yl]-carbamic acid (R)-1-phenyl-ethyl ester 
• 189871-24-7 [(R)-2-(4-Fluoro-phenyl)-3-methyl-5,5-bis-trifluoromethyl-4,5-dihydro-3H-imidazol-4-yl]-carbamic acid (R)-1-phenyl-ethyl ester 
• 189871-27-0 (R)-2-(4-Fluoro-phenyl)-3-methyl-5,5-bis-trifluoromethyl-4,5-dihydro-3H-imidazol-4-ylamine 
• 189871-17-8 2-(4-Fluoro-phenyl)-3-methyl-5,5-bis-trifluoromethyl-4,5-dihydro-3H-imidazol-4-ylamine 
• 189871-34-9 (1S,4R)-4,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid [(R)-2-(4-fluoro-phenyl)-3-methyl-5,5-bis-trifluoromethyl-4,5-dihydro-3H-imidazol-4-yl]-amide 
• 1026752-76-0 2-(4-Fluoro-phenyl)-5-isocyanato-1-methyl-4,4-bis-trifluoromethyl-4,5-dihydro-1H-imidazole 
• 189871-16-7 2-(4-Fluoro-phenyl)-3-methyl-5,5-bis-trifluoromethyl-3,5-dihydro-imidazol-4-ylideneamine 
• 139981-69-4 4-Fluoro-N-[2-(4-fluoro-phenyl)-3-methyl-5,5-bis-trifluoromethyl-3,5-dihydro-imidazol-(4Z)-ylidene]-benzamide 
• 195812-53-4 trans-N-[2-(4-cyanophenyl)-4,5-dihydro-1-methyl-4,4-bis(trifluoromethyl)-1H-imidazol-5-yl]-N-methyl-4-propylcyclohexanecarboxamide 

Relevant academic research and scientific papers

A facile synthesis of 4,4-bis(trifluoromethyl)-imidazolinesvia a novel oxidative imidazole rearrangement

Oxidation of imidazole (1) with singlet oxygen or m-chloroperbenzoic acid affords novel 4,4-bis(trifluoromethyl)imidazolines in high yield via a unique oxidative ring opening and subsequent acid catalyzed dehydrocyclization.