17859-48-2Relevant academic research and scientific papers
Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists.
Perron-Sierra, Francoise,Saint Dizier, Dominique,Bertrand, Marc,Genton, Annie,Tucker, Gordon C,Casara, Patrick
, p. 3291 - 3296 (2002)
A novel series of potent and specific alpha(v) integrin antagonists has been obtained by aminoalkyl substitutions on benzocyloheptene acetic acids as a rigid GD bioisostere. The preferred compounds 1-2, 1-3 and 1-8, showed nano- to subnanomolar IC(50) values on alpha(v)beta(3) and alpha(v)beta(5) integrins, with favorable pharmacokinetics.
