178622-38-3

Basic information

• Product Name: N-DIHYDROCINNAMOYLAMINOCAPROIC ACID
• Synonyms: N-DIHYDROCINNAMOYLAMINOCAPROIC ACID;6-[(1-Oxo-3-phenylpropyl)aMino]hexanoic Acid;6-[(3-Phenylpropionyl)aMino]hexanoic Acid
• CAS NO: 178622-38-3
• Molecular Formula: C₁₅H₂₁NO₃
• Molecular Weight: 263.33214
• Product Categories: Aromatics Compounds;Aromatics
• Mol File: 178622-38-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Solubility: Chloroform, Dichloromethane, DMF, Methanol
• CAS DataBase Reference: N-DIHYDROCINNAMOYLAMINOCAPROIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: N-DIHYDROCINNAMOYLAMINOCAPROIC ACID(178622-38-3)
• EPA Substance Registry System: N-DIHYDROCINNAMOYLAMINOCAPROIC ACID(178622-38-3)

Safety Data

• Hazardous Substances Data: 178622-38-3(Hazardous Substances Data)

Usage

Description

N-Dihydrocinnamoylaminocaproic acid is a white solid compound that serves as a key component in the synthesis of a novel class of hedgehog antagonists derived from Cyclopamine (C988400). This organic compound plays a crucial role in the development of pharmaceuticals targeting the hedgehog signaling pathway, which is implicated in various diseases, including cancer.

Uses

Used in Pharmaceutical Industry:
N-Dihydrocinnamoylaminocaproic acid is used as a synthetic intermediate for the development of hedgehog antagonists. These antagonists are designed to target and inhibit the hedgehog signaling pathway, which is involved in the regulation of cell growth and differentiation. The inhibition of this pathway has shown potential in treating various diseases, particularly cancer.
In the synthesis of hedgehog antagonists derived from Cyclopamine (C988400), N-Dihydrocinnamoylaminocaproic acid serves as a vital building block, enabling the creation of compounds that can effectively modulate the hedgehog signaling pathway. This makes it a valuable component in the ongoing research and development of novel therapeutic agents for the treatment of cancer and other related conditions.

Upstream product

• 645-45-4 hydrocinnamic acid chloride 
• 60-32-2 6-aminohexanoic acid 
• 109318-10-7 2,5-dioxopyrrolidin-1-yl 3-phenylpropanoate 

Downstream Products

• 334616-48-7 N-dihydrocinnamoylaminocaproic acid N-hydroxysuccinimide ester 
• 878204-88-7 N-allyl-6-(3-phenylpropanamido)hexanamide 

Relevant articles and documents

Semisynthetic cyclopamine analogues as potent and orally bioavailable hedgehog pathway antagonists

Herein is reported the synthesis of a novel class of hedgehog antagonists derived from cyclopamine. The acid sensitive D-ring of cyclopamine was homologated utilizing a sequence of chemoselective cyclopropanation and stereoselective acid-catalyzed rearran

REGULATORS OF THE HEDGEHOG PATHWAY, COMPOSITIONS AND USES RELATED THERETO

The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract the phenotypic effects of unwanted activation of a hedgeh

Composition containing a penem or carbapenem antibiotic

Administration of an N-acylated amino acid in association with a penem or carbapenem antibiotic relieves or eliminates the renal problems associated with administration of the antibiotic alone. The amino acid derivative and antibiotic may be formulated together as a composition or administered separately, either simultaneously or sequentially. The composition may be prepared by simple mixing.