178624-90-3

Basic information

• Product Name: 3-METHYL-1-(TOLUENE-4-SULFONYL)-PIPERAZINE
• Synonyms: 3-METHYL-1-(TOLUENE-4-SULFONYL)-PIPERAZINE
• CAS NO: 178624-90-3
• Molecular Formula: C₁₂H₁₈N₂O₂S
• Molecular Weight: 254.35
• Mol File: 178624-90-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-METHYL-1-(TOLUENE-4-SULFONYL)-PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYL-1-(TOLUENE-4-SULFONYL)-PIPERAZINE(178624-90-3)
• EPA Substance Registry System: 3-METHYL-1-(TOLUENE-4-SULFONYL)-PIPERAZINE(178624-90-3)

Safety Data

• Hazardous Substances Data: 178624-90-3(Hazardous Substances Data)

Usage

General Description

3-METHYL-1-(TOLUENE-4-SULFONYL)-PIPERAZINE, also known as 4-(3-methylpiperazin-1-yl)benzenesulfonamide, is a chemical compound that belongs to the piperazine class of organic compounds. It is also classified as a sulfonamide, a type of molecule containing a sulfur atom attached to a nitrogen atom. 3-METHYL-1-(TOLUENE-4-SULFONYL)-PIPERAZINE is commonly used in organic synthesis, pharmaceutical research, and as a building block in the production of various drugs and pharmacological agents. It has also been studied for its potential use as a serotonin receptor antagonist, and has shown promise in the treatment of certain neurological disorders. The chemical structure of 3-METHYL-1-(TOLUENE-4-SULFONYL)-PIPERAZINE consists of a piperazine ring with a methyl group attached to one of the nitrogen atoms, and a toluene-4-sulfonyl group attached to the other nitrogen atom.

Upstream product

• 74879-18-8 (S)-2-methylpiperazine 
• 98-59-9 p-toluenesulfonyl chloride 
• 300547-86-8 ethyl [[2-(methoxyimino)propyl][(4-methylphenyl)sulfonyl]amino]acetate 
• 300547-90-4 [[2-(methoxyimino)propyl][(4-methylphenyl)sulfonyl]amino]acetaldehyde 
• 300547-89-1 N-[(2-methoxyimino)ethyl]-4-methyl-N-(2-oxopropyl)benzenesulfonamide 
• 300547-85-7 N-(2-hydroxypropyl)-N-[(2-methoxyimino)ethyl]-4-methylbenzenesulfonamide 
• 109-07-9 (RS)-2-methylpiperazine 

Downstream Products

• 1026282-97-2 1-{3-[2-(4-Fluoro-phenyl)-[1,3]dioxolan-2-yl]-propyl}-2-methyl-4-(toluene-4-sulfonyl)-piperazine 
• 1544431-58-4 (2S)-1,2-dimethyl-4-(para-toluenesulfonyl)piperazine 

Relevant articles and documents

Tertiary amine-promoted enone aziridination: Investigations into factors influencing enantioselective induction

trans-N-Unsubstituted aziridines were synthesised (up to 77% ee) via a chiral tertiary amine-promoted nucleophilic aziridination of a,b-unsaturated ketones utilising in situ generated N-N ylides (aminimines). A wide range of chiral tertiary amines were sy

7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics

Compound 1 (1-benzyl-3-methyl-4-[4-(4-fluorophenyl)-4- oxobutyl]piperazine), a synthetic intermediate identified as a potential atypical antipsychotic, was selected as the starting point for pharmacological improvement. From 1, sequential structural variations were conducted in order to improve its potency and oral bioavailability. These variations included a series of piperazine, ethanediamine, and piperidine derivatives. The piperidine series afforded some orally potent compounds in the inhibition of apomorphine-induced climbing and hyperactivity in mice, which are regarded as behavioral models predictive of antipsychotic efficacy. Further optimization of these structures led to the highly potent 7-[3-(1- piperidinyl)propoxy]chromenones. Inhibition of stereotypies and induction of catalepsy in rats at doses substantially higher than required for inhibition of climbing suggest an atypical antipsychotic profile, which is assumed to predict a reduced induction of extrapyramidal side effects in humans.