178624-90-3

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
3-METHYL-1-(TOLUENE-4-SULFONYL)-PIPERAZINE is used as a building block for the synthesis of various drugs and pharmacological agents due to its unique chemical structure and properties.
Used in Organic Synthesis:
3-METHYL-1-(TOLUENE-4-SULFONYL)-PIPERAZINE is used as a key intermediate in the organic synthesis of complex molecules, contributing to the development of new chemical entities.
Used in Neurological Disorders Treatment:
3-METHYL-1-(TOLUENE-4-SULFONYL)-PIPERAZINE is used as a potential serotonin receptor antagonist for the treatment of certain neurological disorders, leveraging its ability to modulate serotonin signaling pathways.
Used in Chemical Research:
3-METHYL-1-(TOLUENE-4-SULFONYL)-PIPERAZINE is used as a research tool in chemical research to explore its properties, reactivity, and potential applications in various chemical processes.

Upstream product

• 109-07-9 (RS)-2-methylpiperazine 
• 98-59-9 p-toluenesulfonyl chloride 
• 74879-18-8 (S)-2-methylpiperazine 
• 300547-86-8 ethyl [[2-(methoxyimino)propyl][(4-methylphenyl)sulfonyl]amino]acetate 
• 300547-90-4 [[2-(methoxyimino)propyl][(4-methylphenyl)sulfonyl]amino]acetaldehyde 
• 300547-89-1 N-[(2-methoxyimino)ethyl]-4-methyl-N-(2-oxopropyl)benzenesulfonamide 
• 300547-85-7 N-(2-hydroxypropyl)-N-[(2-methoxyimino)ethyl]-4-methylbenzenesulfonamide 

Downstream Products

• 1026282-97-2 1-{3-[2-(4-Fluoro-phenyl)-[1,3]dioxolan-2-yl]-propyl}-2-methyl-4-(toluene-4-sulfonyl)-piperazine 
• 1544431-58-4 (2S)-1,2-dimethyl-4-(para-toluenesulfonyl)piperazine 

Relevant academic research and scientific papers

Tertiary amine-promoted enone aziridination: Investigations into factors influencing enantioselective induction

trans-N-Unsubstituted aziridines were synthesised (up to 77% ee) via a chiral tertiary amine-promoted nucleophilic aziridination of a,b-unsaturated ketones utilising in situ generated N-N ylides (aminimines). A wide range of chiral tertiary amines were sy

Radical cyclization in heterocycle synthesis. Part 9: A novel synthesis of aminocyclitols and related compounds via stannyl radical cyclization of oxime ethers derived from sugars

Stannyl radical addition-cyclization of oxime ethers derived from D-glucose, D-galactose, and D-xylose proceeded smoothly to afford alkoxyamino alcohols which were effectively converted into two types of glycosidase inhibitors or its candidates such as aminocyclitols, 1-deoxynojirimycin, and 1-deoxygalactostatin via reductive ring-expansion of trans alkoxyamino alcohols. (C) 2000 Elsevier Science Ltd.

7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics

Compound 1 (1-benzyl-3-methyl-4-[4-(4-fluorophenyl)-4- oxobutyl]piperazine), a synthetic intermediate identified as a potential atypical antipsychotic, was selected as the starting point for pharmacological improvement. From 1, sequential structural variations were conducted in order to improve its potency and oral bioavailability. These variations included a series of piperazine, ethanediamine, and piperidine derivatives. The piperidine series afforded some orally potent compounds in the inhibition of apomorphine-induced climbing and hyperactivity in mice, which are regarded as behavioral models predictive of antipsychotic efficacy. Further optimization of these structures led to the highly potent 7-[3-(1- piperidinyl)propoxy]chromenones. Inhibition of stereotypies and induction of catalepsy in rats at doses substantially higher than required for inhibition of climbing suggest an atypical antipsychotic profile, which is assumed to predict a reduced induction of extrapyramidal side effects in humans.