178686-24-3

Basic information

• Product Name: 3-ETHOXY-4-HYDROXY-5-NITROBENZALDEHYDE
• Synonyms: ASISCHEM R35982;AKOS B029213;5-NITROETHYLVANILLIN;3-ETHOXY-4-HYDROXY-5-NITROBENZALDEHYDE;Benzaldehyde, 3-ethoxy-4-hydroxy-5-nitro- (9CI);4-Hydroxy-3-ethoxy-5-nitrobenzaldehyde;2-Ethoxy-4-formyl-6-nitrophenol
• CAS NO: 178686-24-3
• Molecular Formula: C₉H₉NO₅
• Molecular Weight: 211.17
• Product Categories: ETHOXY
• Mol File: 178686-24-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 332.5°Cat760mmHg
• Flash Point: 154.9°C
• Appearance: /
• Density: 1.39g/cm³
• Vapor Pressure: 7.51E-05mmHg at 25°C
• Refractive Index: 1.611
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 3-ETHOXY-4-HYDROXY-5-NITROBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ETHOXY-4-HYDROXY-5-NITROBENZALDEHYDE(178686-24-3)
• EPA Substance Registry System: 3-ETHOXY-4-HYDROXY-5-NITROBENZALDEHYDE(178686-24-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 178686-24-3(Hazardous Substances Data)

Usage

General Description

3-ETHOXY-4-HYDROXY-5-NITROBENZALDEHYDE is a chemical compound that contains a benzene ring with a nitro group, a hydroxyl group, and an ethoxy group attached to it. It is an aldehyde derivative with a molecular formula C9H9NO5 and a molecular weight of 207.17 g/mol. 3-ETHOXY-4-HYDROXY-5-NITROBENZALDEHYDE is commonly used in organic synthesis and chemical research as a building block for the synthesis of various pharmaceuticals, dyes, and other organic compounds. It is known for its strong yellow color and has been used as a fluorescent probe in analytical chemistry and biochemistry. Furthermore, it is important to handle this chemical with caution, as it can be hazardous if not handled properly.

InChI:InChI=1/C9H9NO5/c1-2-15-8-4-6(5-11)3-7(9(8)12)10(13)14/h3-5,12H,2H2,1H3

Upstream product

• 121-32-4 4-hydroxy-3-ethoxybenzaldehyde 

Downstream Products

• 1245939-34-7 [(3S)-3-amino-3-carboxypropyl][(5-ethoxy-4-hydroxy-3-nitrophenyl)hydroxymethyl]phosphinic acid 
• 1245939-19-8 [(3S)-3-(N-benzyloxycarbonyl)amino-3-methoxycarbonylpropyl][(5-ethoxy-4-hydroxy-3-nitrophenyl)hydroxymethyl]phosphinic acid 
• 1283119-69-6 6-cyclopentyl-4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-5-phenyl-3,4-dihydropyrimidin-2(1H)-one 
• 1283117-61-2 3-(4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-2-oxo-6-phenyl-l,2,3,4-tetrahydropyrimidin-5-yl)benzamide 
• 1283119-04-9 (S)-4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-6-(1-methyl-1H-pyrazol-3-yl)-5-(thiophen-3-yl)-3,4-dihydropyrimidin-2(1H)-one 
• 1283119-05-0 (R)-4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-6-(1-methyl-1H-pyrazol-3-yl)-5-(thiophen-3-yl)-3,4-dihydropyrimidin-2(1H)-one 
• 1283118-35-3 4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-5-phenyl-6-(1H-pyrrol-3-yl)-3,4-dihydropyrimidin-2(1H)-one 
• 1283118-99-9 (R)-4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-6-(pyridin-3-yl)-5-(thiophen-3-yl)-3,4-dihydropyrimidin-2(1H)-one 
• 1283118-97-7 (S)-4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-6-(pyridin-3-yl)-5-(thiophen-3-yl)-3,4-dihydropyrimidin-2(1H)-one 
• 1283117-04-3 (R)-4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-6-phenyl-5-(thiophen-3-yl)-3,4-dihydropyrimidin-2(1H)-one 
• 1283117-03-2 (S)-4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-6-phenyl-5-(thiophen-3-yl)-3,4-dihydropyrimidin-2(1H)-one 
• 1283117-79-2 (R)-4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-5-phenyl-6-(pyridin-3-yl)-3,4-dihydropyrimidin-2(1H)-one 
• 1283117-80-5 (S)-4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-5-phenyl-6-(pyridin-3-yl)-3,4-dihydropyrimidin-2(1H)-one 

Relevant articles and documents

Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites

A group III metabotropic glutamate (mGlu) receptor agonist (PCEP) was identified by virtual HTS. This orthosteric ligand is composed by an l-AP4-derived fragment that mimics glutamate and a chain that binds into a neighboring pocket, offering possibilities to improve affinity and selectivity. Herein we describe a series of derivatives where the distal chain is replaced by an aromatic or heteroaromatic group. Potent agonists were identified, including some with a mGlu4 subtype preference, e.g., 17m (LSP1-2111) and 16g (LSP4-2022). Molecular modeling suggests that aromatic functional groups may bind at either one of the two chloride regulatory sites. These agonists may thus be considered as particular bitopic/dualsteric ligands. 17m was shown to reduce GABAergic synaptic transmission at striatopallidal synapses. We now demonstrate its inhibitory effect at glutamatergic parallel fiber-Purkinje cell synapses in the cerebellar cortex. Although these ligands have physicochemical properties that are markedly different from typical CNS drugs, they hold significant therapeutic potential.

4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY

The invention relates to a 4-phenyl-5-oxo-l,4,5,6,7,8-hexahydroquinoline derivative according to Formula (I), wherein the substituents are defined as in the description, or a pharmaceutically salt thereof. The compounds of this invention are potent FSH receptor activators and may be used for treating fertility disorders in e.g. controlled ovarian hyperstimulation and IVF procedures.