178686-24-3

Usage

Uses

Used in Organic Synthesis:
3-ETHOXY-4-HYDROXY-5-NITROBENZALDEHYDE is used as a building block in organic synthesis for the creation of various pharmaceuticals, dyes, and other organic compounds. Its versatile structure allows for the development of a wide range of products in the chemical industry.
Used in Chemical Research:
As a component in chemical research, 3-ETHOXY-4-HYDROXY-5-NITROBENZALDEHYDE aids in the exploration of new chemical reactions and the synthesis of novel compounds. Its presence in experiments can provide insights into the reactivity and behavior of different functional groups.
Used in Analytical Chemistry and Biochemistry:
3-ETHOXY-4-HYDROXY-5-NITROBENZALDEHYDE is used as a fluorescent probe in analytical chemistry and biochemistry. Its strong yellow color and fluorescence properties make it a valuable tool for detecting and analyzing various substances in a laboratory setting.
Used in Dye Production:
In the dye industry, 3-ETHOXY-4-HYDROXY-5-NITROBENZALDEHYDE is used as a precursor for the production of dyes. Its color properties contribute to the development of dyes with specific characteristics, suitable for various applications.
It is important to handle 3-ETHOXY-4-HYDROXY-5-NITROBENZALDEHYDE with care, as it can be hazardous if not managed properly. Proper safety measures should be taken to ensure the safe use of this chemical compound in all its applications.

InChI:InChI=1/C9H9NO5/c1-2-15-8-4-6(5-11)3-7(9(8)12)10(13)14/h3-5,12H,2H2,1H3

Upstream product

• 121-32-4 4-hydroxy-3-ethoxybenzaldehyde 

Downstream Products

• 857629-79-9 (E)-N,N-diethyl-2-cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)acrylamide 
• 1245939-19-8 [(3S)-3-(N-benzyloxycarbonyl)amino-3-methoxycarbonylpropyl][(5-ethoxy-4-hydroxy-3-nitrophenyl)hydroxymethyl]phosphinic acid 
• 1245939-34-7 [(3S)-3-amino-3-carboxypropyl][(5-ethoxy-4-hydroxy-3-nitrophenyl)hydroxymethyl]phosphinic acid 
• 1283117-65-6 4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-6-(4-morpholinophenyl)-5-phenyl-3,4-dihydropyrimidin-2(1H)-one 
• 1283117-58-7 6-(2,4-difluorophenyl)-4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-5-phenyl-3,4-dihydropyrimidin-2(1H)-one 
• 1283117-57-6 4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-6-(4-hydroxyphenyl)-5-phenyl-3,4-dihydropyrimidin-2(1H)-one 
• 1283117-94-1 4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-5-phenyl-6-(thiophen-3-yl)-3,4-dihydropyrimidin-2(1H)-one 
• 1283117-59-8 4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-6-(furan-3-yl)-5-phenyl-3,4-dihydropyrimidin-2(1H)-one 
• 1283118-02-4 4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-6-(naphthalen-2-yl)-5-phenyl-3,4-dihydropyrimidin-2(1H)-one 
• 1283119-71-0 6-cyclohexyl-4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-5-(thiophen-3-yl)-3,4-dihydropyrimidin-2(1H)-one 
• 1283118-45-5 4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-6-(pyridin-3-yl)-5-(thiophen-3-yl)-3,4-dihydropyrimidin-2(1H)-one 
• 1283117-85-0 4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-5-phenyl-6-(pyridin-4-yl)-3,4-dihydropyrimidin-2(1H)-one 
• 1283117-01-0 4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-6-phenyl-5-(thiophen-2-yl)-3,4-dihydropyrimidin-2(1H)-one 
• 1283117-25-8 5-(3-chlorophenyl)-4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-6-phenyl-3,4-dihydropyrimidin-2(1H)-one 

Relevant academic research and scientific papers

Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites

A group III metabotropic glutamate (mGlu) receptor agonist (PCEP) was identified by virtual HTS. This orthosteric ligand is composed by an l-AP4-derived fragment that mimics glutamate and a chain that binds into a neighboring pocket, offering possibilities to improve affinity and selectivity. Herein we describe a series of derivatives where the distal chain is replaced by an aromatic or heteroaromatic group. Potent agonists were identified, including some with a mGlu4 subtype preference, e.g., 17m (LSP1-2111) and 16g (LSP4-2022). Molecular modeling suggests that aromatic functional groups may bind at either one of the two chloride regulatory sites. These agonists may thus be considered as particular bitopic/dualsteric ligands. 17m was shown to reduce GABAergic synaptic transmission at striatopallidal synapses. We now demonstrate its inhibitory effect at glutamatergic parallel fiber-Purkinje cell synapses in the cerebellar cortex. Although these ligands have physicochemical properties that are markedly different from typical CNS drugs, they hold significant therapeutic potential.

4-Phenyl-5-Oxo-1,4,5,6,7,8,- Hexahydroquinoline Derivatives as Medicaments for the Treatment of Infertility

The invention relates to a 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivative according to Formula (I), wherein the substituents are defined as in the description, or a pharmaceutically salt thereof. The compounds of this invention are potent FSH receptor activators and may be used for treating fertility disorders in e.g. controlled ovarian hyperstimulation and IVF procedures.

4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY

The invention relates to a 4-phenyl-5-oxo-l,4,5,6,7,8-hexahydroquinoline derivative according to Formula (I), wherein the substituents are defined as in the description, or a pharmaceutically salt thereof. The compounds of this invention are potent FSH receptor activators and may be used for treating fertility disorders in e.g. controlled ovarian hyperstimulation and IVF procedures.