857629-79-9 Usage
Uses
(2E)-2-Cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide is an impurity of Entacapone (E558500), a peripherally acting inhibitor of catechol-O-methyl transferase (COMT), an enzyme involved in the metabolism of catecholamine neurotransmitters and related drugs. Antiparkinsonian.
Check Digit Verification of cas no
The CAS Registry Mumber 857629-79-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,7,6,2 and 9 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 857629-79:
(8*8)+(7*5)+(6*7)+(5*6)+(4*2)+(3*9)+(2*7)+(1*9)=229
229 % 10 = 9
So 857629-79-9 is a valid CAS Registry Number.
857629-79-9Relevant articles and documents
IMPROVED PROCESS FOR THE PREPARATION OF ENTACAPONE
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Page/Page column 6-7, (2008/06/13)
The invention disclosed in this application relates to an improved process for the preparation of the Entacapone which comprises. (i)reacting 3-alkoxy- 4-hydroxy-5-nitrobenzadehyde with N,N-diethylaminocyanoactamide in the presence of mild acid catalyst and a solvent at a temperature in the range of 50-115 °C, to get the 3-O-alkylated (methyl or ethyl) Entacapone and treating with acid catalysts in the presence of organic base and solvents at temperature in the range of 20-60 °C to get Entacapone.
