178744-41-7

Upstream product

• 27460-85-1 N-(tert-butoxycarbonyl)-D-(4-hydroxyphenyl)glycine 
• 178744-39-3 L-4-fluoro-3-nitrophenylalanine methyl ester 
• 143323-49-3 (R)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-hydroxyphenyl)acetate 
• 178744-40-6 (S)-2-[(R)-2-tert-Butoxycarbonylamino-2-(4-hydroxy-phenyl)-acetylamino]-3-(4-fluoro-3-nitro-phenyl)-propionic acid methyl ester 
• 74-88-4 methyl iodide 

Downstream Products

• 178744-42-8 (S)-2-[(R)-2-[(R)-2-tert-Butoxycarbonylamino-2-(3,5-diisopropoxy-4-methoxy-phenyl)-acetylamino]-2-(4-methoxy-phenyl)-acetylamino]-3-(4-fluoro-3-nitro-phenyl)-propionic acid methyl ester 
• 178744-34-8 C₄₅H₄₉F₂N₇O₁₆ 

Relevant academic research and scientific papers

SNAr Based Macrocyclization via Biaryl Ether Formation: Application in Natural Product Synthesis

A new macrocyclization method based on intramolecular SNAr reaction developed recently in this laboratory has been summarized. Mild conditions, high yield and versatility are the characteristic features of the present method. Application to the synthesis of 14-, 16-and 17-membered macrocycles found in natural products has been demonstrated.

Synthesis of a model bicyclic C-O-D-O-E ring of vancomycin by a one-pot, double SNAr based macrocyclization

Double cyclization of linear pentapeptide 3 by treatment with CsF in DMF at -5°C gives a model bicyclic CODOE ring 2 of vancomycin in a one-pot fashion.