178744-42-8

Basic information

• Product Name: L-Phenylalanine, (2R)-N-[(1,1-dimethylethoxy)carbonyl]-2-[4-methoxy-3,5-bis(1-methyleth oxy)phenyl]glycyl-(2R)-2-(4-methoxyphenyl)glycyl-4-fluoro-3-nitro-, methyl ester
• CAS NO: 178744-42-8
• Molecular Formula: C39H49FN4O12
• Molecular Weight: 784.836
• Mol File: 178744-42-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: L-Phenylalanine, (2R)-N-[(1,1-dimethylethoxy)carbonyl]-2-[4-methoxy-3,5-bis(1-methyleth oxy)phenyl]glycyl-(2R)-2-(4-methoxyphenyl)glycyl-4-fluoro-3-nitro-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Phenylalanine, (2R)-N-[(1,1-dimethylethoxy)carbonyl]-2-[4-methoxy-3,5-bis(1-methyleth oxy)phenyl]glycyl-(2R)-2-(4-methoxyphenyl)glycyl-4-fluoro-3-nitro-, methyl ester(178744-42-8)
• EPA Substance Registry System: L-Phenylalanine, (2R)-N-[(1,1-dimethylethoxy)carbonyl]-2-[4-methoxy-3,5-bis(1-methyleth oxy)phenyl]glycyl-(2R)-2-(4-methoxyphenyl)glycyl-4-fluoro-3-nitro-, methyl ester(178744-42-8)

Safety Data

• Hazardous Substances Data: 178744-42-8(Hazardous Substances Data)

Upstream product

• 217494-28-5 [2-(4-benzyl-2-oxo-oxazolidin-3-yl)-1-(3,5-bisisopropyloxy-4-methoxy-phenyl)-2-oxo-ethyl]carbamic acid tert-butyl ester 
• 178744-37-1 (R)-3-[(R)-2-Azido-2-(3,5-diisopropoxy-4-methoxy-phenyl)-acetyl]-4-benzyl-oxazolidin-2-one 
• 178744-36-0 (R)-4-Benzyl-3-[2-(3,5-diisopropoxy-4-methoxy-phenyl)-acetyl]-oxazolidin-2-one 
• 178744-35-9 3,5-diisopropyloxy-4-methoxyphenyl acetic acid 
• 918446-56-7 5-Bromomethyl-1,3-diisopropoxy-2-methoxy-benzene 
• 171738-31-1 4-methoxy-3,5-diisopropyloxybenzaldehyde 
• 918446-55-6 (3,5-Diisopropoxy-4-methoxy-phenyl)-methanol 
• 27460-85-1 N-(tert-butoxycarbonyl)-D-(4-hydroxyphenyl)glycine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 178744-39-3 L-4-fluoro-3-nitrophenylalanine methyl ester 
• 178744-41-7 (S)-2-[(R)-2-tert-Butoxycarbonylamino-2-(4-methoxy-phenyl)-acetylamino]-3-(4-fluoro-3-nitro-phenyl)-propionic acid methyl ester 
• 178744-40-6 (S)-2-[(R)-2-tert-Butoxycarbonylamino-2-(4-hydroxy-phenyl)-acetylamino]-3-(4-fluoro-3-nitro-phenyl)-propionic acid methyl ester 
• 143323-49-3 (R)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-hydroxyphenyl)acetate 
• 178744-38-2 (R)-N-(t-butoxycarbonyl)-(3,5-diisopropyloxy-4-methoxyphenyl)glycine 

Downstream Products

• 178744-34-8 C₄₅H₄₉F₂N₇O₁₆ 
• 195306-16-2 (S)-2-[(R)-2-[(R)-2-[(S)-2-tert-Butoxycarbonylamino-2-(3-isopropoxy-phenyl)-acetylamino]-2-(3,5-dihydroxy-4-methoxy-phenyl)-acetylamino]-2-(4-methoxy-phenyl)-acetylamino]-3-(4-fluoro-3-nitro-phenyl)-propionic acid methyl ester 

Relevant articles and documents

SNAr Based Macrocyclization via Biaryl Ether Formation: Application in Natural Product Synthesis

A new macrocyclization method based on intramolecular SNAr reaction developed recently in this laboratory has been summarized. Mild conditions, high yield and versatility are the characteristic features of the present method. Application to the synthesis of 14-, 16-and 17-membered macrocycles found in natural products has been demonstrated.