178755-44-7Relevant academic research and scientific papers
Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1
Kallander, Lara S.,Washburn, David,Hilfiker, Mark A.,Eidam, Hilary Schenck,Lawhorn, Brian G.,Prendergast, Joanne,Fox, Ryan,Dowdell, Sarah,Manns, Sharada,Hoang, Tram,Zhao, Steve,Ye, Guosen,Hammond, Marlys,Holt, Dennis A.,Roethke, Theresa,Hong, Xuan,Reid, Robert A.,Gampe, Robert,Zhang, Hong,Diaz, Elsie,Rendina, Alan R.,Quinn, Amy M.,Willette, Bob
, p. 736 - 740 (2018/07/25)
Bone Morphogenetic Protein 1 (BMP1) inhibition is a potential method for treating fibrosis because BMP1, a member of the zinc metalloprotease family, is required to convert pro-collagen to collagen. A novel class of reverse hydroxamate BMP1 inhibitors was
HYDROXY FORMAMIDE DERIVATIVES AND THEIR USE
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Paragraph 0381; 0382, (2016/12/16)
Disclosed are compounds having the formula: wherein R1, R2 and R3 are as defined herein, and methods of making and using the same, including use as inhibitors of BMP1, TLL1 and/or TLL2 and in treatment of diseases associated with BMP1, TLL1 and/or TLL2 activity.
HYDROXY FORMAMIDE DERIVATIVES AND THEIR USE
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Page/Page column 71, (2015/07/23)
Disclosed are compounds having the formula (I): wherein R1, R2 and R3 are as defined herein, and methods of making and using the same, including use as inhibitors of BMP1, TLL1 and/or TLL2 and in treatment of diseases associated with BMP1, TLL1 and/or TLL2 activity.
Evaluation of hadacidin analogues
Tibrewal, Nidhi,Elliott, Gregory I.
supporting information; experimental part, p. 517 - 519 (2011/02/25)
Several derivatives of hadacidin have been developed and evaluated for activity against adenylosuccinate synthetase.
Peptidyl hydroxamic acids as methionine aminopeptidase inhibitors
Hu, Xubo,Zhu, Jinge,Srivathsan, Sumant,Pei, Dehua
, p. 77 - 79 (2007/10/03)
A new class of methionine aminopeptidase (MetAP) inhibitors, which contain an internal hydroxamate (N-acyl-N-alkylhydroxylamine) core as the metal-chelating group, has been designed, synthesized, and tested. The compounds exhibited reversible, competitive inhibition against Escherichia coli MetAP as well as human MetAP-1 and MetAP-2. The most potent inhibitor had a Ki value of 2.5 μM and >20-fold selectivity toward E. coli MAP.
Synthesis and aldose reductase inhibitory activity of some N-(aroyl)-N-(arylalkyloxy)-glycines and β-alanines
Macchia,Menchini,Nencetti,Orlandini,Rossello,Belfiore
, p. 255 - 260 (2007/10/03)
Some N-(aroyl)-N-(phenylethyloxy)glycines (C) and N-(aroyl)-N-(arylmethyloxy)β-alanines (D) were synthesised and tested as aldose reductase inhibitors (ARIs). Compounds C and D differ from the previously reported ARIs of type A in the presence of a furthe
