178876-83-0

Basic information

• Product Name: Methyl 6-amino-3-bromopicolinate
• Synonyms: Methyl 6-amino-3-bromopicolinate;Methyl 6-amino-3-bromopyridine-2-carboxylate;methyl 6-amino-3-bromo-2-pyridinecarboxylate;6-Amino-3-bromo-pyridine-2-carboxylic acid methyl ester
• CAS NO: 178876-83-0
• Molecular Formula: C₇H₇BrN₂O₂
• Molecular Weight: 231.05
• Product Categories: blocks;Bromides;Carboxes;Pyridines
• Mol File: 178876-83-0.mol

Chemical Properties

• Boiling Point: 333.4°Cat760mmHg
• Flash Point: 155.4°C
• Appearance: /
• Density: 1.662g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.608
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 1.12±0.10(Predicted)
• CAS DataBase Reference: Methyl 6-amino-3-bromopicolinate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 6-amino-3-bromopicolinate(178876-83-0)
• EPA Substance Registry System: Methyl 6-amino-3-bromopicolinate(178876-83-0)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 178876-83-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
Methyl 6-amino-3-bromopicolinate is used as a building block in organic synthesis for the preparation of complex organic compounds. Its ability to undergo nucleophilic substitution, metal-catalyzed coupling, and condensation reactions allows for the creation of a wide range of molecules with potential applications in various fields.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, Methyl 6-amino-3-bromopicolinate is utilized as a key intermediate for the development of new pharmaceuticals. Its unique structure and reactivity enable the synthesis of biologically active molecules with potential therapeutic effects.
Used in Drug Development:
Methyl 6-amino-3-bromopicolinate has potential applications in the development of new drugs. Its versatile chemical properties allow for the design and synthesis of novel drug candidates with improved efficacy and selectivity.
Used in Agrochemicals:
Methyl 6-amino-3-bromopicolinate also finds use in the development of agrochemicals, where its reactivity and structural properties can be leveraged to create new molecules with pesticidal or herbicidal activities.
Used in Fine Chemicals:
Methyl 6-amino-3-bromopicolinate is utilized in the production of fine chemicals, which are high-purity chemicals used in various industries, including pharmaceuticals, fragrances, and flavors. Its ability to form complex organic compounds makes it a valuable component in the synthesis of specialty chemicals.

InChI:InChI=1/C7H7BrN2O2/c1-12-7(11)6-4(8)2-3-5(9)10-6/h2-3H,1H3,(H2,9,10)

Upstream product

• 36052-26-3 methyl 6-aminopyridine-2-carboxylate 
• 1824-81-3 2-Amino-6-methylpyridine 
• 5327-33-3 2-acetylamino-6-methylpyridine 
• 26893-72-1 6-acetamido-picolinic acid 
• 1033201-61-4 6-amino-3-bromopicolinic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 23628-31-1 6-aminopicolinic acid 

Downstream Products

• 1037840-90-6 methyl 3-bromo-6-(dibenzylamino)pyridine-2-carboxylate 
• 1319069-28-7 6-amino-3-methyl-pyridine-2-carboxylic acid methyl ester 
• 1319069-37-8 2-[2-amino-8-(4-chloro-phenyl)-6-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl]-propan-2-ol 
• 1214342-46-7 6-amino-3-(3-fluorophenyl)picolinic acid 
• 1622243-02-0 6-amino-3-(3-fluorophenyl)-N-methoxy-N-methylpicolinamide 
• 1622243-03-1 (6-amino-3-(3-fluorophenyl)pyridin-2-yl)(4-fluorophenyl)methanone 
• 1622242-69-6 2-(4-(ethylsulfonyl)phenyl)-N-(6-(4-fluorobenzoyl)-5-(3-fluorophenyl)pyridin-2-yl)acetamide 
• 1214359-92-8 methyl 6-amino-3-(3-fluorophenyl)picolinate 

Relevant articles and documents

HPK1 ANTAGONISTS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.

TRISUBSTITUTED HETEROCYCLIC DERIVATIVES AS ROR GAMMA MODULATORS

The present invention provides trisubstituted heterocyclic derivatives of formula (I), which may be therapeutically useful, more particularly as RORγ modulators; (I) in which R1, R2, R3, Ra, X, L, m and ring A have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention of diseases or disorder, in particular their use in diseases or disorder where there is an advantage in modulating RORγ receptor. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the trisubstituted heterocyclic derivatives of formula (I) together with a pharmaceutically acceptable carrier, diluent or excipient therefor.

APOPTOSIS-INDUCED AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES

Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.

APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES

Disclosed are compounds which inhibit the activity of anti-apoptotic Bc1-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bc1-xL protein.

GAMMA SECRETASE MODULATORS

The invention relates to compounds of formula wherein R1, R1′, R2, R3, n, A, and hetaryl are defined herein or to pharmaceutically active acid addition salts thereof. The present compounds of formula I are modulators for amyloid beta and thus, they may be useful for the treatment or prevention of a disease associated with the deposition of β-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.

GAMMA SECRETASE MODULATERS

The invention relates to compounds of formula ( I ) wherein R1/R1' are independently from each other hydrogen, halogen, lower alkoxy or cyano; R2 is lower alkyl, halogen, lower alkoxy, lower alkyl substituted by halogen, lower alkoxy substituted by halogen, lower alkyl substituted by OR, =0, -C(O)O-lower alkyl, -C(O)NH-lower alkyl, cyano, CH2-O-lower alkyl, cycloalkyl, NRR'or is -O-(CH2)o-phenyl optionally substituted by halogen, or is -(CH2)o-phenyl optionally substituted by one, two or three substituents, selected from halogen, -(CH2)o-cyano, lower alkyl, lower alkyl substituted by halogen, lower alkyl substituted by hydroxy, C(O)H, -CH2-NH2-, -CH2-NH-C(O)O-lower alkyl, -CH2-NH-C(O)-lower alkyl, -CH2-NH-lower alkyl, -CH2-NH-S(O)2-lower alkyl, lower alkoxy or by lower alkoxy substituted by halogen, or is -(CH2)o-cycloalkyl, or is -(CH2)o-heterocycloalkyl which is optionally substituted by halogen, CF3, lower alkyl, -CH2CN, -C(O)-lower alkyl, -C(O)O-lower alkyl or S(O)2-lower alkyl, or is heteroaryl selected from the group consisting of furanyl, pyrazinyl, pyridinyl, benzooxazolyl or benzoimidazolyl which are optionally substituted by lower alkyl, or is 4-methyl-3,4-dihydro-2H-benzo[l,4]oxazine R and R' are independently from each other hydrogen or lower alkyl, and o is 0 or 1; R3 may occur once or twice and is lower alkyl; A is Formula a), b), c), d), e), f), h), i), j) and Formula k); R2' is hydrogen, lower alkyl, lower alkyl substituted by halogen, C(O)-lower alkyl, S(O)2-lower alkyl or phenyl optionally substituted by halogen; hetaryl is a 5 or 6 membered N, S or O-containing heteroaryl group; n is O, 1, 2 or 3; if n is 2 or 3, R2 may be the same or not; or to pharmaceutically active acid addition salts thereof. The present compounds of formula ( I ) are modulators for amyloid beta and thus, they may be useful for the treatment or prevention of a disease associated with the deposition of β-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi- infarct dementia, dementia pugilistica and Down syndrome.

HETEROARYL SUBSTITUTED PIPERIDINES

The invention relates to compounds of formula where hetaryl I, hetaryl II, R1,R2,R3, R4, m, n, and o are as defined in the specification or to pharmaceutically active acid addition salts thereof. The compounds of formula I are modulators for amyloid beta and thus may be useful for the treatment or prevention of a disease associated with the deposition of β-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.

PIPERIDINE DERIVATIVES

The invention relates to compounds of formula (I). Hetaryl I is a five or six membered heteroaryl group, containing 1 to 3 heteroatoms, selected from O, S or N; hetaryl II is a five or six membered heteroaryl group, containing 1 to 3 heteroatoms, selected from O, S or N, or is a two membered ring system containing 1 to 4 heteroatoms selected from S, O or N, wherein at least one ring is aromatic in nature; R1 is lower alkyl, lower alkoxy, lower alkyl substituted by halogen, or halogen; R2 is halogen, lower alkyl, lower alkoxy, hydroxy, lower alkyl substituted by halogen, lower alkyl substituted by hydroxy or benzo[1,3]dioxolyl, or is -(CHR)p-phenyl, optionally substituted by halogen, lower alkyl, lower alkoxy, S(O)2 -1ower alkyl, cyano, nitro, lower alkoxy substituted by halogen, dimethylamino, -(CH2)P-NHC(O)O-Iower alkyl, or lower alkyl substituted by halogen, and R is hydrogen, halogen, hydroxy or lower alkoxy, or is cycloalkenyl or cycloalkyl, optionally substituted by hydroxy or lower alkyl substituted by halogen, or is a five or six membered heteroaryl group, containing 1 to 3 heteroatoms, selected from O, S or N, which is optionally substituted by halogen, lower alkyl, lower alkoxy or dimethylamino, or is O-phenyl, optionally substituted by halogen, or is heterocycloalkyl, optionally substituted by halogen, hydroxy, lower alkyl substituted by halogen or C(O)O-lower alkyl; R3 is hydrogen, lower alkyl, cyano or phenyl; R4 is lower alkoxy, lower alkyl or halogen; p is 0 or 1; n is 0, 1 or 2; if n is 2 then R4 may be the same or different; m is 0, 1 or 2; if m is 2 then R1 may be the same or different; o is 0, 1, 2 or 3, if o is 2 or 3 then R2 may be the same or different; or to pharmaceutically active acid addition salts thereof. The compounds of formula (I) are modulators for amyloid beta and thus, they may be useful for the treatment or prevention of a disease associated with the deposition of beta- amyloid in the brain, in particular Alzheimer?s disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome

ANTI PARASITIC DIHYDROAZOLE COMPOUNDS AND COMPOSITIONS COMPRISING SAME

The present invention relates to novel dihydroazole of formula (I) and salts thereof: Wherein R1, A1, A2, G, X and Y are as defined in the description, compositions thereof, processes for their preparation and their uses t

ANTIPARISITIC DIHYDROAZOLE COMPOUNDS AND COMPOSITIONS COMPRISING SAME

The present invention relates to novel dihydroazole of formula (I) and salts thereof: Wherein R1, A1, A2, G, X and Y are as defined in the description, compositions thereof, processes for their preparation and their uses t