26893-72-1

Basic information

• Product Name: 6-Acetamidopicolinic acid, 6-(Acetylamino)pyridine-2-carboxylic acid
• Synonyms: 6-Acetamidopicolinic acid, 6-(Acetylamino)pyridine-2-carboxylic acid;6-Acetamidopyridine-2-carboxylic acid 98%;6-Acetamidopicolinic acid;6-acetamidopyridine-2-carboxylic acid;6-acetamido-2-pyridinecarboxylic acid;6-Acetamidopyridine-2-carboxylicacid98%
• CAS NO: 26893-72-1
• Molecular Formula: C₈H₈N₂O₃
• Molecular Weight: 180.16
• Product Categories: blocks;Pyridines
• Mol File: 26893-72-1.mol
• Article Data: 21

Chemical Properties

• Melting Point: 227-229 °C(Solv: ethanol (64-17-5))
• Boiling Point: 489 °C at 760 mmHg
• Flash Point: 249.5 °C
• Appearance: /
• Density: 1.404 g/cm³
• Vapor Pressure: 2.25E-10mmHg at 25°C
• Refractive Index: 1.628
• Storage Temp.: 2-8°C
• PKA: 3.43±0.10(Predicted)
• CAS DataBase Reference: 6-Acetamidopicolinic acid, 6-(Acetylamino)pyridine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Acetamidopicolinic acid, 6-(Acetylamino)pyridine-2-carboxylic acid(26893-72-1)
• EPA Substance Registry System: 6-Acetamidopicolinic acid, 6-(Acetylamino)pyridine-2-carboxylic acid(26893-72-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37
• Hazardous Substances Data: 26893-72-1(Hazardous Substances Data)

Usage

Chemical Properties

White solid

Uses

6-Acetamidopicolinic Acid is a chemical reagent used in the synthesis of calixarene based picolinamide ligands for use in radioactive waste treatment

InChI:InChI=1/C8H8N2O3/c1-5(11)9-7-4-2-3-6(10-7)8(12)13/h2-4H,1H3,(H,12,13)(H,9,10,11)

Upstream product

• 1824-81-3 2-Amino-6-methylpyridine 
• 108-24-7 acetic anhydride 
• 5327-33-3 2-acetylamino-6-methylpyridine 

Downstream Products

• 69142-64-9 ethyl 6-aminopicolinate 
• 23628-31-1 6-aminopicolinic acid 
• 36052-26-3 methyl 6-aminopyridine-2-carboxylate 
• 79651-64-2 (6-Amino-pyridin-2-yl)-methanol 
• 178876-83-0 methyl 6-amino-3-bromo-pyridine-2-carboxylate 
• 178876-82-9 6-amino-5-bromo-pyridine-2-carboxylic acid methyl ester 
• 1319069-37-8 2-[2-amino-8-(4-chloro-phenyl)-6-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl]-propan-2-ol 
• 1319069-28-7 6-amino-3-methyl-pyridine-2-carboxylic acid methyl ester 
• 1319068-85-3 2-[2-Amino-8-(4-chloro-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-5-yl]-propan-2-ol 
• 1235486-04-0 2-(2,3,4,5,6-pentafluorophenoxycarbonyl)-6-(acetylamino)pyridine 
• 947689-77-2 N-(6-{3-[4-(benzylthio)phenyl]-1,2,4-oxadiazol-5-yl}pyridin-2-yl)acetamide 
• 947689-82-9 N-(6-{3-[4-({[3-(acetylamino)phenyl]amino}sulfonyl)phenyl]-1,2,4-oxadiazol-5-yl}pyridin-2-yl)acetamide 
• 637336-00-6 6-acetylamino-pyridine-2-carboxylic acid {4-[3-cyclopropylmethyl-1-(2-fluorobenzyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-ylmethyl]-phenyl}-methyl-amide 
• 98953-28-7 6-acetylamino-pyridine-2-carboxylic acid methyl ester 

Relevant articles and documents

Cation-halide transport through peptide pores containing aminopicolinic acid

Synthetic pores that selectively transport ions of biological significance through membranes could be potentially used in medical diagnostics or therapeutics. Herein, we report cation-selective octapeptide pores derived from alanine and aminopicolinic acid. The ion transport mechanism through the pores has been established to be a cation-chloride symport. The cation-chloride co-transport is biologically essential for the efficient functioning of the central nervous system and has been implicated in diseases such as epilepsy. The pores formed in synthetic lipid bilayers do not exhibit any closing events. The ease of synthesis as well as infinite lifetimes of these pores provides scope for modifying their transport behaviour to develop sensors.

GAMMA SECRETASE MODULATORS

The invention relates to compounds of formula wherein R1, R1′, R2, R3, n, A, and hetaryl are defined herein or to pharmaceutically active acid addition salts thereof. The present compounds of formula I are modulators for amyloid beta and thus, they may be useful for the treatment or prevention of a disease associated with the deposition of β-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.

HETEROARYL SUBSTITUTED PIPERIDINES

The invention relates to compounds of formula where hetaryl I, hetaryl II, R1,R2,R3, R4, m, n, and o are as defined in the specification or to pharmaceutically active acid addition salts thereof. The compounds of formula I are modulators for amyloid beta and thus may be useful for the treatment or prevention of a disease associated with the deposition of β-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.